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Updated: Feb 7, 2026

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Detection and Isolation of Circulating Melanoma Cells using Photoacoustic Flowmetry

Published on: November 25, 2011

メラノーマに対するT細胞を解き放つGARPに注意：グルココルチコイドはいかにして

Merel Roest¹, Nuno Padrão¹, Wilbert Zwart¹

¹Department of Oncogenomics, Oncode Institute, The Netherlands Cancer Institute, Amsterdam, the Netherlands.

Cancer discovery

|February 6, 2026

Abstract:

Earnshaw and colleagues discover a tumor-intrinsic mechanism driven by glucocorticoid receptor (GR) activation, in which GR downregulates glycoprotein A repetitions predominant (GARP), thereby inhibiting TGFβ signaling and releasing CD8+ T cells to exert their antitumor activity. This mechanistic insight significantly advances our understanding of how GR shapes tumor immunity and highlights new avenues for overcoming immune checkpoint blockade resistance in melanoma and other cancers. See related article by Earnshaw et al., p. 345.

キーワード:

グルココルチコイド受容体 GARP TGFβシグナル伝達 CD8+ T細胞メラノーマ免疫チェックポイント阻害腫瘍免疫がん免疫療法

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Mindfulness in Motion MIM: An Onsite Mindfulness Based Intervention MBI for Chronically High Stress Work Environments to Increase Resiliency and Work Engagement

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Published on: July 1, 2015

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

A Robust Discovery Platform for the Identification of Novel Mediators of Melanoma Metastasis

Published on: March 8, 2022

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