妊娠中のSARS-CoV-2感染後のCOVID-19後遺症:コホート調査に基づく質問票調査
Cecilie Bøge Paulsen1, Cecilie Isgaard2, Lone Krebs3,4
1Department of Anesthesiology, Copenhagen University Hospital - Hvidovre-Amager, Copenhagen, Denmark.
Frontiers in medicine
|February 6, 2026
まとめ
SARS-CoV-2に感染した妊婦の半数以上が、8週間以上持続するCOVID-19後遺症の症状を経験した。妊娠中の有症候性感染は、長期的なCOVIDを発症する可能性を高めたが、重症度や妊娠期間はリスクに影響しなかった。
科学分野:
- 産婦人科
- 感染症
- 公衆衛生
背景:
- SARS-CoV-2感染後の持続的な症状を特徴とするCOVID-19後遺症は、重大な健康問題である。
- 妊娠中に感染した女性は、産科以外のコホートと比較して、COVID-19後遺症を発症するリスクが高い可能性がある。
研究 の 目的:
- 妊娠中にSARS-CoV-2感染を経験した女性におけるCOVID-19後遺症の有病率と持続期間を調査すること。
- 感染期間または病気の重症度がCOVID-19後遺症の発症に影響を与えるかどうかを判断すること。
主な方法:
- デンマークで全国的な前向きコホート調査を実施した。
- 妊娠中にSARS-CoV-2陽性反応が出た女性(2020年3月~2021年11月)を対象にオンラインアンケートを実施した。
- アンケートの少なくとも70%を完了した920人の参加者からのデータを分析した。
主要な成果:
- 参加者の69.1%がCOVID-19後遺症の症状を経験し、50.1%が8週間以上持続する症状を報告した。
- 一般的な症状には、疲労、嗅覚/味覚の変化、脱毛が含まれ、ほとんどは感染後4週間以内に発症した。
- 妊娠中の有症候性SARS-CoV-2感染は、COVID-19後遺症の可能性が高いことと関連していた。
- 病気の重症度または感染期間が、COVID-19後遺症の発症と関連があるという所見はなかった。
結論:
- 妊娠中のSARS-CoV-2感染の約半数が、持続的なCOVID-19後遺症の症状を発症する。
- 妊娠中の有症候性感染は、長期的なCOVIDを発症する重要な要因である。
- 病気の重症度と感染期間は、COVID-19後遺症のその後のリスクとは相関しなかった。
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