インフルエンザおよびSARS-CoV-2の同時感染または逐次感染に対する局所的および全身的宿主応答

Tong Zhu¹, Liying Wang², Chaoying Yan¹

¹Department of Neonatology and Institute of Pediatrics, Children's Medical Center, First Hospital of Jilin University, Jilin University, Changchun, Jilin, China.

Frontiers in cellular and infection microbiology

|February 6, 2026

まとめ

インフルエンザとSARS-CoV-2の同時感染は、肺損傷と炎症を悪化させます。これらのメカニズムを理解することは、これらの呼吸器感染症の予防と治療を改善するための鍵となります。

科学分野:

呼吸器感染症
ウイルス学
免疫学

背景:

インフルエンザウイルスは1世紀以上にわたって流行してきましたが、SARS-CoV-2（COVID-19）は2019年12月に発生しました。
SARS-CoV-2はパンデミックから風土病へと移行しており、長期的なヒトとの共存を示唆しています。
インフルエンザとSARS-CoV-2の同時感染は、患者の転帰を悪化させることが観察されています。

主な方法:

臨床観察およびメカニズム研究の文献レビュー。
同時感染における病理学的および免疫学的応答の分析。
宿主と病原体の相互作用に関する現在の理解の統合。

結論:

インフルエンザとSARS-CoV-2の同時感染は、疾患の重症度を著しく増加させます。
根本的なメカニズムに関するさらなる研究が不可欠です。
予防と臨床管理のための強化された戦略が必要です。

キーワード:

SARS-CoV-2 感染インフルエンザインフルエンザウイルス肺病変全身応答

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