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Updated: Feb 7, 2026

A Protocol of Manual Tests to Measure Sensation and Pain in Humans
Published on: December 19, 2016
接触性蕁麻疹検査:臨床実装のための実践的プロトコル
Vanessa Husmann1, Douglas L Powell1, Jamie P Schlarbaum1
1From the Department of Dermatology, University of Utah School of Medicine, Salt Lake City, Utah, USA.
Abstract:
Background: Contact urticaria (CU) is an underdiagnosed condition representing a significant proportion of allergic skin diseases. Standard patch testing typically cannot detect immediate hypersensitivity reactions characteristic of CU. Despite the need for accurate diagnosis to guide management decisions, specialized immediate-testing protocols required for CU identification lack standardization and are not readily available at most dermatology/allergy centers.Objective: To present a practical CU testing protocol that addresses current diagnostic gaps for immediate-type reactions and can be implemented in dermatology/allergy practices.Methods: We describe our institutional protocol combining short-term occlusive testing with selective skin prick testing for CU diagnosis. The protocol includes patient selection criteria, allergen series and testing materials, step-by-step procedure, safety measures, clinic workflow optimization, and billing considerations.Conclusions: Our CU testing protocol is a method useful for diagnosing immediate hypersensitivity reactions missed by patch testing alone. Incorporating this technique may result in identification of culprit allergens and optimize management through targeted avoidance strategies.
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