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Updated: Jul 21, 2026

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

クローン病患者における心理的苦痛に影響を与える要因：コモン・センス・モデルに基づくパス解析

YoonJi Roh¹, Hye-Ah Yeom¹

¹College of Nursing, The Catholic University of Korea, 222 Banpo-daero, Seocho-gu, Seoul, Republic of Korea.

Asian nursing research

|February 6, 2026

要旨

Purpose:

This study aimed to investigate the influence of disease activity, disease-related knowledge, illness perception and coping strategies on psychological distress in patients with Crohn's disease, using a path analysis based on common-sense-model.

Methods:

This was a cross-sectional study. A total of 399 adult patients were recruited from an online support community in Korea between October and December 2024. Data were collected through online self-reported questionnaires, using the Harvey-Bradshaw Index, the Inflammatory Bowel Disease Knowledge, the Korean version of the Brief Illness Perception Questionnaire, the Korean version of the Coping Strategy Indicator, and the Korean version of the Kessler Psychological Distress Scale. The data were analyzed using SPSS/WIN 24.0 and AMOS 29.0. Path analysis was used to examine how disease-related knowledge and disease activity influences psychological distress through illness perception and coping strategies.

Results:

Both disease activity and disease-related knowledge were found to influence psychological distress through a serial mediation effect of illness perception and avoidance coping. The avoidance coping model showed acceptable model fit. Disease activity and disease-related knowledge had a negative effect on avoidance coping. The path from disease-related knowledge to avoidance coping showed the strongest effect within the research model.

Conclusions:

This study demonstrated the need for an integrated approach to reduce disease activity and increase disease-related knowledge factors to effectively alleviate psychological distress in patients with Crohn's disease.

キーワード:

クローン病態度対処スキル健康知識実践心理的苦痛病状重症度指数

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