植物性飲料の心血管代謝アウトカムへの影響:システマティックレビューおよびネットワークメタアナリシス
Sabina Wallerer1, Julia Stadelmaier1, Maria Petropoulou2
1Institute for Evidence in Medicine, Medical Center - University of Freiburg / Medical Faculty - University of Freiburg, Germany.
Advances in nutrition (Bethesda, Md.)
|February 6, 2026
まとめ
植物性ミルク代替品は、牛乳と比較して心血管代謝の違いは限定的である。大豆飲料はLDLコレステロールおよび血圧を低下させる可能性があるが、エビデンスの確実性は低く、さらなる研究が必要である。
科学分野:
- 栄養科学; 心血管の健康; 食事介入
背景:
- 植物性ミルク代替品の世界的な需要の増加。牛乳と比較した場合の健康への影響に関する不確実性。心血管代謝アウトカムに関する比較分析の必要性。
研究 の 目的:
- 植物性飲料を互いに、また牛乳と比較して系統的にレビューし、ネットワークメタアナリシス(NMA)を実施すること。心血管代謝の健康マーカーへの影響を評価すること。観察された違いのエビデンスの確実性を評価すること。
主な方法:
- MEDLINE、Cochrane CENTRAL、Web of Science、およびトライアルレジストリの系統的検索。3週間以上の期間のランダム化比較試験(RCT)を含めること。ランダム効果モデルおよびGRADE確実性評価を使用したネットワークメタアナリシス。
主要な成果:
- 14件のRCT(543人の参加者)で、大豆、米、オーツ麦飲料、牛乳を比較しました。全体的な心血管代謝の違いは限定的でした。大豆飲料はLDLコレステロール(確実性低)および血圧(確実性低)を低下させる可能性があります。オーツ麦飲料は総コレステロールをわずかに低下させる可能性があります(確実性非常に低い)。
結論:
- 植物性飲料と牛乳との間に有意な心血管代謝の違いがあるというエビデンスは限定的です。大豆飲料はLDLコレステロールおよび血圧に潜在的な利点を示します。エビデンスの確実性が低いことは、質の高いRCTの必要性を強調しています。
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