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Updated: May 12, 2026

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Unraveling Entropic Rate Acceleration Induced by Solvent Dynamics in Membrane Enzymes

Published on: January 16, 2016

酵素としてのマックスウェルの悪魔：酵素拡散の強化による化学平衡からの定常状態からの逸脱

Shunsuke Ichii^1,2, Tetsuhiro S Hatakeyama³, Kunihiko Kaneko^3,4

¹The University of Tokyo, Department of Physics, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.

Physical review letters

|February 6, 2026

Abstract:

Enhanced enzyme diffusion (EED), in which the diffusion coefficient of an enzyme transiently increases during catalysis, has been extensively reported experimentally, although its existence remains under debate. In this Letter, we investigate what macroscopic consequences would arise if EED exists. Through numerical simulations and theoretical analysis, we demonstrate that such enzymes can act as Maxwell's demons: They use their enhanced diffusion as a memory of the previous catalytic reaction, to gain information and drive steady-state chemical concentrations away from chemical equilibrium. Our theoretical analysis identifies the conditions under which this process could operate and discusses its possible biological relevance.

キーワード:

強化酵素拡散マックスウェルの悪魔化学平衡酵素触媒記憶

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