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Updated: Feb 8, 2026

An Efficient Method to Obtain Dedifferentiated Fat Cells
Published on: July 15, 2016
脱分化型および未分化型メラノーマ:病理診断におけるカメレオン
Ann-Kristin Iro1, Abbas Agaimy2
1Department of Dermatology, Klinikum Nürnberg, Paracelsus Medical University, Prof.-Ernst-Nathan-Str. 1, 90419 Nürnberg, Germany.
Abstract:
Melanoma showing subclonal (dedifferentiated) or global (undifferentiated) loss of all routinely used immunophenotypic melanocytic markers has been the topic of several studies in recent years. These recent studies highlighted a significant underrecognition of this diagnostically challenging phenomenon and paved the way for appropriate systemic therapy utilizing established and emerging melanoma-tailored therapy protocols that should enable achievement of the highest therapy response rate and, hence, improve prognosis. This review summarizes these recent developments related to the topic.
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