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Updated: Feb 9, 2026

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Sentinel Lymph Node Mapping and Biopsy for Endometrial Cancer at Early Stage with Laparoscopy

Published on: August 19, 2021

子宮内膜がん管理への分子分類の統合

Giorgio Bogani¹, Amy Jamieson², Giuseppe Caruso³

¹Department of Surgery, Fondazione IRCCS Istituto Nazionale Dei Tumori, Milano, Italy.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

|February 7, 2026

Abstract:

Endometrial carcinoma is biologically heterogeneous. Molecular classification derived from The Cancer Genome Atlas (TCGA) identifies clinically relevant molecular subtypes, each with distinct prognostic and therapeutic implications. FIGO 2023 recognizes tumor biology in staging, and the new 2025 ESGO guidelines incorporate molecular data into risk-stratified management. This is a position paper on the incorporation of molecular classification in endometrial cancer. We focused on molecular taxonomy, diagnostic surrogates, prognostic validation, and therapeutic implications of immune and targeted agents. The five molecular subtypes (POLEmut; MMRd/MSI-H; p53abn; NSMP ER-positive; NSMP ER-negative) provide stronger prognostic discrimination than grade or histotype alone. We recommend that molecular subtype should guide adjuvant treatment de-escalation or intensification, inform the use of immunotherapy and targeted agents, and refine risk stratification beyond conventional parameters. We also discussed implementation challenges, including test standardization, reporting, equity of access, and areas of ongoing uncertainty. This position paper aims to support consistent, equitable, and biologically informed management of endometrial carcinoma in contemporary practice.

キーワード:

子宮内膜がん MMR欠損/MSI-H 分子分類 POLE変異プレシジョン・メディシン

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