関連する実験動画

Updated: Feb 9, 2026

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Comparing Eye-tracking Data of Children with High-functioning ASD, Comorbid ADHD, and of a Control Watching Social Videos

Published on: December 7, 2018

ADHD児における黒質鉄含有量と注意および認知制御との関連：臨床的および認知的プロファイル

Hugo A E Morandini¹, Sjoerd B Vos², Ranila Bhoyroo³

¹Complex Attention and Hyperactivity Disorders Service, Child and Adolescent Health Service, Nedlands, WA, Australia; Division of Psychiatry, UWA Medical School, Faculty of Health & Medical Sciences, The University of Western Australia, Australia.

Journal of affective disorders

|February 7, 2026

要旨

Background:

ADHD has been associated with impaired central nervous dopaminergic pathways. Brain iron is an essential cofactor for the synthesis of dopamine and the substantia nigra (SN) is a significant pool of dopaminergic neurons playing a central role in the activity of the nigrostriatal pathway. The present study investigated SN iron content in children with ADHD, its relationship with ADHD symptom severity and cognitive performance.

Methods:

Neuroimaging and phenotypical data were extracted from the Healthy Brain Network dataset. After initial screening, 54 medication-naïve children with ADHD and 44 neurotypical (NT) children (8-12 year) were included. ADHD symptom severity was extracted from the Child Behavior Checklist (CBCL) Parent report and working memory (WM) and inhibitory control scores from the National Institute of Health toolbox.

Results:

A mixed between-within subjects ANOVA revealed no significant difference in SN iron content between medication-naïve children with ADHD and NT (partial eta squared = 0.001, p = .79). In the ADHD group, Spearman's correlation revealed a significant inverse relationship between left (r = -0.38; p < .01) and right (r = -0.33; p = .01) SN iron content and CBCL Attention Problems T score, while in the NT group left SN iron content significantly correlated with inhibitory control (r = 0.36; p = .02).

Conclusions:

Although there was no difference in nigral iron content between both groups, higher SN iron content was associated with lower attention problems in children with ADHD and higher SN iron content was associated with better inhibitory control in NT children.

キーワード:

ADHD 注意の問題脳鉄抑制 MRI 黒質

さらに関連する動画

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

Published on: January 31, 2022

A Colorimetric Method for Measuring Iron Content in Plants

A Colorimetric Method for Measuring Iron Content in Plants

Published on: September 7, 2018

関連する概念動画

Cognitive Dissonance

Cognitive Dissonance

Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...

Stereotype Content Model

Stereotype Content Model

The Stereotype Content Model (SCM) was first proposed by Susan Fiske and her colleagues (Fiske, Cuddy, Glick & Xu, 2002; see also Fiske, 2012 and Fiske, 2017). The SCM specifies that when someone encounters a new group, they will stereotype them based on two metrics: warmth—or that group’s perceived intent, and how likely they are to provide help or inflict harm—and competence—or their ability to carry out that objective. Depending on the warmth-competence...

Cognition and Behavior

Cognition and Behavior

Social psychology examines the complex interplay between individual mental processes and social interactions. Historically, the field was divided into two domains: social behavior and social cognition. Researchers focusing on social behavior analyzed actions within social contexts, such as conformity, aggression, or cooperation. Meanwhile, social cognition researchers investigated how people perceive, interpret, and mentally represent their social environments. However, modern perspectives no...

Cognitive Learning

Cognitive Learning

Cognitive learning is based on purposive behavior, incidental learning, and insight learning.
E. C. Tolman's theory of purposive behavior emphasizes that much behavior is goal-directed. He argued that to understand behavior, we must look at the entire sequence of actions leading to a goal. For instance, high school students study hard, not just due to past reinforcement but also to achieve the goal of getting into a good college.
Tolman introduced the idea that behavior is influenced by...

Language and Cognition

Language and Cognition

Language serves as a bridge between ideas and communication, influencing how individuals perceive and interact with the world. Psychologists have long debated whether language shapes thought or vice versa. This discussion gained grip with Edward Sapir and Benjamin Lee Whorf in the 1940s, who proposed that language determines thought, a concept known as linguistic determinism. They suggested that the vocabulary and structure of a language influence how its speakers think and perceive reality.

Cognitive Therapy

Cognitive Therapy

Cognitive therapy, pioneered by Aaron T. Beck in the 1960s, is a structured approach to addressing psychological distress by focusing on the influence of thoughts on emotions and behaviors. All cognitive therapies involve the basic assumption that human beings have control over their feelings, and that how individuals feel about something depends on how they think about it. Unlike psychoanalytic methods that delve into unconscious processes or humanistic approaches emphasizing...