間葉系間質細胞由来のFlt3Lは常在樹状細胞を維持する
Arpa Aintablian1, Ayse N Kilinc1, Angela Riedel2
1Mildred Scheel Early Career Centre (MSNZ) for Cancer Research Würzburg, University Hospital Würzburg and University Würzburg, Würzburg, Germany.
Abstract:
Dendritic cell (DC) maintenance and positioning are essential for their function in lymph nodes. Wu et al. identify gremlin1 (Grem1)+ fibroblastic reticular cells as critical source of niche-specific Fms-like tyrosine kinase 3 ligand (Flt3L) for conventional DC maintenance in health and disease, highlighting stromal cells as key regulators of immunity.
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