高周波領域を副伝導路アブレーションの電気生理学的指標として:ピーク周波数マッピングによる空間的分離の特性評価
Takashige Sakio1, Takashi Kanda2, Hitoshi Minamiguchi2
1Cardiovascular Division, Osaka Keisatsu Hospital, Osaka, Japan.
Heart rhythm
|February 8, 2026
まとめ
オムニポーラ技術近接場マッピングは、成功した副伝導路アブレーション部位に隣接するが、それとは異なる高周波領域を明らかにする。この空間的差異は、房室回帰性頻脈の正確なカテーテルアブレーションのための新しい標的を提供する。
科学分野:
- 電気生理学
- 心臓不整脈マッピング
背景:
- カテーテルアブレーション(CA)は、副伝導路(AP)による房室回帰性頻脈(AVRT)の治癒的治療法です。
- 従来のマッピング技術では、APの正確な局在化は困難な場合があります。
- オムニポーラ技術近接場(OTNF)は新しい周波数分析を提供しますが、APアブレーションへの臨床応用は証明されていません。
研究 の 目的:
- OTNFピーク周波数マップによって同定された高周波領域と成功したAPアブレーション部位との空間的関係を調査すること。
- OTNFがカテーテルアブレーション中のAP局在化の精度を向上させることができるかどうかを判断すること。
主な方法:
- AVRTに対するCAが成功した33人の患者からのOTNFデータの遡及的分析。
- 取得されたオープンウィンドウマッピングデータのオフラインピーク周波数(PF)分析。
- アブレーション部位でのPF、近傍での最高PF、空間距離、および方向性変位の測定。
主要な成果:
- 成功したアブレーション部位は高周波領域(平均332 ± 206 Hz)にありましたが、絶対的な最高PFは隣接していました(平均435 ± 56 Hz; p < 0.01)。
- 最も高いPF部位は、成功したアブレーション部位から中央値64%(IQR: 0-6 mm)で空間的にずれていました。
- 方向性分析では、64%で共定位、27%で反時計回りのシフト、9%で時計回りのシフトが示されました。
結論:
- OTNFマップ上の高周波領域は、成功したAPアブレーション部位に隣接していますが、空間的には異なります。
- この定量可能な空間的分離は、新しい電気生理学的標的です。
- OTNFマッピングは、AVRTのAPカテーテルアブレーションの精度と効率を高める可能性があります。
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