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肝細胞癌に対する免疫原性動脈塞栓化学療法を増強する水素発生器

Lei Cao¹, Li Ren², Longlin Yin³

¹Central Laboratory and Ultrasound Medicine and Computational Cardiology Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, PR China; Department of Radiology, Sichuan Academy of Medical Sciences, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu 610072, Sichuan, PR China; Department of Interventional Radiology, Affiliated Cancer Hospital of Guizhou Medical University, Guiyang, Guizhou, PR China.

Journal of controlled release : official journal of the Controlled Release Society

|February 8, 2026

まとめ

本研究では、水素発生器を用いた肝細胞癌（HCC）に対する新しい動脈塞栓化学療法（TACE）法を紹介する。このアプローチは腫瘍微小環境を再構築し、化学免疫療法を増強し、治療成績を向上させる。

科学分野:

腫瘍学; 生体医工学; 免疫療法

背景:

肝細胞癌（HCC）に対する従来の動脈塞栓化学療法（TACE）は、腫瘍微小環境（TME）の低酸素症と酸性症のために限界に直面している。これらの要因はしばしば治療効果を損ない、腫瘍の再発につながる。

研究の目的:

TMEを再構築してHCCに対する化学免疫療法の応答を増強する革新的なTACEシステムを開発すること。局所的な水素放出とエピルビシン（EPI）送達の相乗効果を調査すること。

主な方法:

局所的な水素放出のためのEPIヨード油塞栓システムに水素発生器（水素化カルシウム、CaH₂）を組み込んだ。TACEによるナノCaH₂粒子の併用送達により、水素ガス（H₂）とカルシウムイオン（Ca²⁺）を放出させた。

主要な成果:

水素放出はがん細胞のミトコンドリア機能を破壊し、酸素消費を削減し、腫瘍低酸素症を緩和して、化学療法抵抗性に対抗した。エピルビシン（EPI）は免疫原性細胞死（ICD）を誘導し、抗腫瘍免疫応答を活性化した。水酸化物イオンはTMEの酸性化を中和し、免疫抑制を軽減し、化学免疫療法の相乗効果を増幅した。

結論:

新しいCaH₂統合TACE戦略は、TMEを効果的に再構築し、HCCの化学免疫療法を増強する。このアプローチは、TACEの効果とがん治療における臨床的有用性の向上に大きな可能性を示している。

キーワード:

CaH(2)従来の動脈塞栓化学療法 H(2)療法免疫療法腫瘍微小環境

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