関連する実験動画

Updated: Feb 10, 2026

In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors

In Vitro Rearing of Solitary Bees: A Tool for Assessing Larval Risk Factors

Published on: July 16, 2018

指標症例における二次的な麻疹伝播に関連する危険因子

Yuki Takahashi¹, Hideo Tanaka², Toshiyuki Shibata¹

¹Health and Medical General Affairs Division, Osaka Prefectural Government.

Journal of epidemiology

|February 8, 2026

要旨

Background:

Limited information has been shown quantitatively assessed factors associated with the risk of secondary transmission in measles index cases.

Method:

We collected data on measles index cases reported in Osaka Prefecture between November 2018 and March 2019, along with their close contacts. Secondary attack rates (SARs) in contacts of index cases were calculated and compared depending on the vaccination status, classical or modified measles and other risk factors in index cases. For the multivariate analyses, we used binary logistic regression to adjust for these potential confounding factors on the secondary transmission and calculated the adjusted odds ratio (aOR) for the SARs.

Result:

A total of 105 index cases were included, involving 9,846 close contacts, with 72 secondary cases identified. A significant negative association between the number of vaccinations received by index cases and the risk of secondary infection in his/her close contacts (p < 0.01). Index cases who had received one vaccine dose had an aOR of 0.22 (95% CI: 0.08-0.65), while those with two or more doses had an aOR of 0.25 (95% CI: 0.07-0.85). Index cases who did not exhibit all three classic measles symptoms had a significantly lower risk of causing secondary infections compared to those who presented with all three symptoms (aOR: 0.12, 95% CI: 0.03-0.39).

Conclusion:

The indirect protective effect of measles vaccination would present important evidence supporting the further strengthening of vaccination policies.

キーワード:

麻疹伝播ワクチン接種指標症例リスク因子

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