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体外循環後全身性炎症反応症候群:有病率、予測因子、および転帰
J J Nuño-Pulido1, R Gopar-Nieto2, G Rojas-Velasco3
1Cardiology Department, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Revista espanola de anestesiologia y reanimacion
|February 9, 2026
まとめ
体外循環(CPB)を受けた心臓手術患者の約3分の1に全身性炎症反応症候群(SIRS)が発生し、出血や腎障害などの合併症のリスクが増加する。CPB後の患者予後のためには、SIRSの早期特定が極めて重要である。
科学分野:
- 循環器病学
- 集中治療医学
- 外科的合併症
背景:
- 全身性炎症反応症候群(SIRS)は、心臓手術、特に体外循環(CPB)後の一般的な合併症である。
- SIRSは罹患率と死亡率の上昇に関連しているが、血行動態と転帰に対する正確な影響は明確にする必要がある。
研究 の 目的:
- CPBを伴う心臓手術患者におけるSIRSの有病率を決定すること。
- SIRSと術前因子、術中変数、血行動態、血管作動薬の必要性、および有害転帰との関連を調査すること。
主な方法:
- CPBを伴う心臓手術を受けた成人患者546人を対象とした後向き観察研究。
- 患者をSIRS群と非SIRS群に分類した。
- 統計解析には、Shapiro-Wilk、Mann-Whitney U、カイ二乗、Fisherの正確確率検定、およびロジスティック回帰を使用した。
主要な成果:
- SIRSは、ICU入室時に患者の31.86%で特定され、主に白血球増多と頻脈によって示された。
- SIRS患者は、より多くの血管作動薬を必要とし、縦隔出血、血管拡張症候群、低心拍出量症候群、急性腎障害、および入院中死亡の有意に高いオッズを示した。
- SIRS患者では、炎症マーカーの上昇が認められた。
結論:
- SIRSは、術後の心臓手術患者において蔓延しており、臨床的に重要である。
- SIRSスコアは、リスク層別化のための有用なツールとして機能する。
- 早期のSIRS特定に基づく標的介入は、患者の転帰を改善する可能性がある。
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