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Updated: Feb 11, 2026

Automatic Laser-based Geometry Capture for Finite Element Analysis of Weld Beads
Published on: July 25, 2025
毛髪由来残存ケラチンベースヒドロゲルとカルシウムを用いたアトルバスタチン捕捉、放出、およびインビトロ活性の実験的および有限要素解析
Evan A Carroll1, Andrew J Tarabokija1, Henna Chaudhry2
1Bioengineering Program, Department of Engineering, Hofstra University, Hempstead, New York, USA.
Abstract:
Excessive fibrosis impairs tissue regeneration by promoting extracellular matrix deposition and fibroblast activation. This study introduces keratin-based hydrogels (KRT) derived from residual human hair as sustainable carriers for localized atorvastatin (Ator) delivery. Calcium incorporation (CKRT) enhanced electrostatic interactions with Ator, improving sequestration and modulating release kinetics. Comprehensive characterization of KRT included chemical composition (FTIR, DSC), charge properties (pI = 5.5; net negative charge = -15.43 µmol/g), porosity (89%), and rheology (shear-thinning, linear viscoelastic region up to 24.5% strain, thermal stability to 68°C). Ator release followed Korsmeyer-Peppas kinetics (r2 > 95%), and finite element analysis validated experimental profiles (r2 = 82%-95%) while estimating diffusivity reductions from 569 to 0.06 µm2/s within the gel matrix. In vitro assays confirmed CKRT biocompatibility (ISO 10993-5) and preserved Ator bioactivity, with EC50 values of 208 µm for mesenchymal stem and 389 µm for fibroblast cell lines. These findings demonstrate that CKRT provides a robust platform for controlled anti-fibrotic drug delivery, supported by extensive physicochemical and mechanical characterization.
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