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Updated: Feb 11, 2026

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Regenerative Therapy by Suprachoroidal Cell Autograft in Dry Age-related Macular Degeneration: Preliminary In Vivo Report

Published on: February 12, 2018

二次円孔性黄斑円孔の自然閉鎖および再発例：症例報告

Carolina Minelli Martines¹, Amanda Latuffe Soares Damião¹, Marina Gasparoni Teixeira Soares¹

¹Ophthalmology, Hospital das Clínicas, Faculty of Medicine, University of São Paulo (HCFMUSP), São Paulo, BRA.

|February 10, 2026

Abstract:

Full-thickness macular holes (FTMHs) are defects of the central retina that cause clinically significant symptoms, including reduced visual acuity. Spontaneous closure may occur in a minority of cases, and pars plana vitrectomy (PPV) remains the gold-standard treatment. This report describes a patient who had previously undergone PPV and, during follow-up, was diagnosed with an FTMH at the Hospital das Clínicas, Faculty of Medicine, University of São Paulo (HCFMUSP), for whom surgical intervention was initially indicated. Prior to the scheduled surgery, the macular hole (MH) closed spontaneously. Several months later, the lesion recurred, and vitrectomy was again recommended. However, during preoperative follow-up, a second spontaneous closure was observed. To date, the patient has remained under clinical observation, and no surgical intervention has been required for this condition. This case highlights the dynamic behavior of secondary FTMHs and emphasizes the importance of longitudinal optical coherence tomography (OCT) follow-up in selected patients.

キーワード:

円孔性黄斑円孔特発性黄斑円孔眼内レンズを用いた硝子体手術再発性黄斑円孔再開した黄斑円孔自然閉鎖した黄斑円孔

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Quantifying Spontaneous Ca2+ Fluxes and their Downstream Effects in Primary Mouse Midbrain Neurons

Quantifying Spontaneous Ca2+ Fluxes and their Downstream Effects in Primary Mouse Midbrain Neurons

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Efficient Generation of hiPSC Neural Lineage Specific Knockin Reporters Using the CRISPR/Cas9 and Cas9 Double Nickase System

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