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関連する概念動画

What is Gene Expression?01:42

What is Gene Expression?

197.0K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
197.0K
What is Gene Expression?01:36

What is Gene Expression?

11.6K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
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Cell Specific Gene Expression01:58

Cell Specific Gene Expression

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5.6K
Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

6.7K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
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関連する実験動画

Updated: Feb 12, 2026

Constructing and Visualizing Models using Mime-based Machine-learning Framework
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AGEP_TWAS：遺伝子発現レベルを組織で予測するための深層学習ベースのフレームワーク

Sizhe Wang, Zhichao Zhou, Chen Li

    IEEE transactions on computational biology and bioinformatics
    |February 10, 2026
    PubMed
    まとめ

    本研究では、AGEP_TWASという新しい遺伝子発現予測手法を紹介します。これは、ランドマーク遺伝子を使用して組織全体の遺伝子発現レベルを正確に予測し、既存のモデルを上回ります。この進歩は、遺伝子機能の理解とトランスクリプトーム全体関連研究（TWAS）の改善に役立ちます。

    科学分野:

    キーワード:
    遺伝子発現予測ランドマーク遺伝子TWAS深層学習ゲノミクスバイオインフォマティクス

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    Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
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    Using an Automated Cell Counter to Simplify Gene Expression Studies: siRNA Knockdown of IL-4 Dependent Gene Expression in Namalwa Cells
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    • ゲノミクス
    • バイオインフォマティクス
    • 計算生物学

    背景:

    • 組織全体での遺伝子発現予測は、機能ゲノミクスおよびトランスクリプトーム全体関連研究（TWAS）にとって重要です。
    • 従来の遺伝子発現予測手法は非効率的であり、欠損一塩基多型（SNP）を考慮しないため、予測能力が制限されます。
    • 細胞状態を反映するランドマーク遺伝子は、ゲノム全体の遺伝子発現を予測するための有望なアプローチを提供します。

    結論:

    • AGEP_TWASは、特に従来の予測が困難な遺伝子に関して、遺伝子発現予測における重要な進歩を提供します。
    • ランドマーク遺伝子を活用し、欠損SNPを処理するこの手法の能力は、予測精度と効率を向上させます。
    • AGEP_TWASは、機能ゲノミクス、TWASの推進、および複雑な形質に関連する遺伝子の特定に実用的な意味を持ちます。