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Updated: Feb 12, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

ペニシリンおよびスルホンアミドのアレルギーとスティーブンス・ジョンソン症候群/中毒性表皮壊死症に関連する要因

Abeo Hayath Mousse¹, Sylvie Bregigeon², Laurent Hocqueloux³

¹Department of Infectious Diseases, University Hospital of Reims, Reims, France.

AIDS (London, England)

|February 10, 2026

要旨

Background:

People with HIV (PWH) are more susceptible to drug reactions than the general population. This study aimed to investigate the prevalence of, and demographic characteristics associated with a history of penicillin and sulfonamide allergy and Stevens-Johnson syndrome/toxic epidermal necrolysis (SJS/TEN), and to assess whether HLA-B∗57:01 is associated with these drug reactions among PWH followed in a large French multicenter cohort.

Methods:

All PWH followed from January 2000 to December 2023 with available results for HLA-B∗57:01 were included. Logistic regression models were used to identify associations between each drug allergy (outcome variable) and explanatory variables.

Results:

Among 35,924 PWH, the prevalence of penicillin and sulfonamide allergy and SJS/TEN were 1.05% (95%CI 0.94-1.16), 1.01% (95%CI 0.91-1.11) and 0.15% (95%CI 0.11-0.19), respectively. AIDS status was significantly associated with a higher risk of penicillin and sulfonamide allergy and SJS/TEN; while female sex was associated with sulfonamide allergy and SJS/TEN. Being born in mainland France, other European countries, and North Africa was associated with a higher risk of penicillin allergy (OR 1.88 [95%CI, 1.13-3.42], p = 0.02), while being born in Sub-Saharan Africa was associated with a lower risk of penicillin allergy (OR 0.39 [95% CI, 0.19-0.81], p = 0.009) and sulfonamide allergy (OR 0.57 [95%CI, 0.34-0.95], p = 0.03). The association between HLA-B∗57:01 and penicillin allergy was positive but statistically non-significant (OR 1.34 [95%CI, 0.87-1.97], p = 0.16).

Conclusion:

In the combined antiretroviral therapy era, the prevalence of both penicillin and sulfonamide allergy is low. Our study confirms ethnic differences in penicillin and sulfonamide allergy.

キーワード:

コーカサス系集団 Dat’AIDSコホート HIV HLA-B*57:01 HLA関連薬疹スティーブンス・ジョンソン症候群抗生物質アレルギー βラクタムアレルギーペニシリンアレルギーサハラ以南アフリカスルホンアミド中毒性表皮壊死症

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