アルツハイマー病マウスモデルにおける異なる食事制限レジメンの認知機能および病理学的マーカーへの影響：系統的レビューおよびメタアナリシス

Dietary restriction (DR) has emerged as a promising non-pharmacological intervention for Alzheimer's disease (AD). This systematic review and meta-analysis provides the first comprehensive comparison of five dietary restriction regimens in Alzheimer's disease mouse models. Analysis of 23 studies demonstrates that caloric restriction yields the most consistent benefits. While intermittent fasting exhibits model-dependent efficacy-improving recognition memory but exacerbating neuroinflammation in 5×FAD models. The fasting-mimicking diet showed the largest effect size. From a geroscience perspective, these findings support a precision nutrition framework for Alzheimer's disease, suggesting that future interventions should be tailored to individual pathological profile, inflammatory status, and impaired cognitive subdomains to optimize therapeutic efficacy.