安全かつ効果的なハイパーサーミアがん治療のための円偏波マイクロストリップアンテナアレイのハイブリッドインテリジェント最適化

Hyperthermia therapy is a developing adjuvant oncologic technique that induces controlled heating (40-45 °C) in the affected area to enhance the therapeutic effect of radiation or chemotherapy, while avoiding damage to surrounding healthy tissue. In this work, a 16-element circularly polarized microstrip antenna array operating at 2.45 GHz is proposed to improve the accuracy and safety of electromagnetic hyperthermia treatment. Localization of the target is performed using image-based clustering. A particle swarm optimization (PSO)-based phase-only approach is used to optimize the beamformer weights for maximum power deposition at the tumor location. Hotspot suppression is performed using a Null Space Jacobian (NSJ)-based method to mitigate superficial heating after target localization and power optimization. This adaptive control is executed in a near real-time manner during treatment delivery, with a total closed-loop update time below 1.5 s. Simulation studies using a full-wave electromagnetic solver coupled with a bioheat model verify accurate power focusing, minimal energy leakage, and improved thermal safety. Phantom-based experimental validation further demonstrates uniform heating and effective suppression of non-target temperature rise. The proposed system demonstrates a hybrid intelligent approach for improving treatment efficacy and has strong potential for further development as an adaptive prototype verified through phantom experiments.