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Updated: Feb 12, 2026

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
10:07

Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

Published on: June 23, 2013

68.6K

老化に起因する原始B細胞の減少は,ROS活性化Fos/CCL3シグナル伝達経路経由で骨髄マクロファージの骨格クラステオゲネシスを強化する

Ruiqing Sun1, Lan Luo1, Yang Chen1

  • 1Department of Pediatric Dentistry, Peking University School and Hospital of Stomatology & National Center for Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Research Center of Oral Biomaterials and Digital Medical Devices& Beijing Key Laboratory of Digital Stomatology & NHC Key Laboratory of Digital Stomatology & NMPA Key Laboratory for Dental Materials, No.22, Zhongguancun South Avenue, Haidian District, Beijing, 100081, P.R. China.

Immunity & ageing : I & A
|February 11, 2026
PubMed
まとめ

老齢性骨粗鬆症における酸化ストレスにより,Bリンパ球の免疫衰老が加速され,前身のB細胞が減少する. これは,骨を吸収するオステオクラストの形成を促進する経路を活性化させ,治療目標としてCCR1アンタゴニストを示唆します.

キーワード:
Fos/CCL3シグナル伝達経路について免疫衰退による衰退.マクロファージは,マクロファージのプロジェニターB細胞は,ROSOS ROSは,ROSOSという名前で呼ばれています.老年性骨粗鬆症の高齢化について

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