組織性硬化症における腸脳相互作用の障害の有病率の定量化

Kate Seaton¹, Alannah Quinlivan^2,3, Nava Ferdowsi³

¹Department of General Medicine, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.

Neurogastroenterology and motility

|February 11, 2026

まとめ

組織性硬化症の患者はしばしば腸-脳相互作用障害を経験し,胃腸の健康と生活の質に影響を及ぼします. これらの障害を認識することは,SScに関連した胃腸疾患の管理に不可欠です.

科学分野:

胃腸内科胃腸内科
自己免疫疾患自己免疫疾患
神経胃腸内科神経胃腸内科

背景:

システミック硬化症 (SSc) は,稀な自己免疫疾患であり,しばしば胃腸不動性を示します.
SScに関連する胃腸症状における腸-脳軸の障害の役割は不明である.

研究の目的:

組織性硬化症の患者における腸-脳相互作用 (DGBI) 障害のような症状の有病率を決定する.
DGBIの症状とSScの重症度,日々の機能,生活の質との関連を調査する.

主な方法:

横断的な調査では,イライラ性腸症候群 (IBS),機能性消化不良 (FD),機能性消化不良,および食後ストレス症候群 (PPDS) のローマ4条基準が評価されました.
検証されたアンケート (SF-36,HAQ-DI,UCLA GIT 2.0,ScleroID) で,生活の質,機能,疾患への影響が評価されました.
線形回帰では,DGBIの症状と臨床パラメータの関連性を分析した.

主要な成果:

101人のSSc患者のうち,21人がFDの基準を満たし,18人がIBSの基準を満たした.
IBSとFDは,より重度のSSc胃腸疾患 (GIT2.0スコア) と有意に関連していました.
FDは,生活の質の低下 (SF-36 PCS) と相関しており,IBSとFDは,全体的にSScの影響 (ScleroID) の増加と関連していた.

結論:

調査対象となったSSc患者の約5分の1が,DGBIのような症状の診断基準を満たしていた.
腸-脳相互作用の障害は,SSc胃腸疾患の評価において考慮されるべきである.
SSc患者のサブセットは,DGBIの併存症状を経験し,その症状が全体的な臨床表現に寄与する可能性があります.

キーワード:

腸脳相互作用の障害機能性消化不良症である.消化器系は,胃腸にイライラ性腸症候群 (IBS) とは組織性硬化症 (全身性硬化症) とは

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