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Updated: Feb 12, 2026

Methodology for Accurate Detection of Mitochondrial DNA Methylation
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Published on: May 20, 2018

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ベルベリンC9誘導体 選択的細胞毒性は,ミトコンドリア損傷とDNAインターキャレーションのバランスに依存します

Anastasiia Yu Kolchanova1, Konstantin G Lyamzaev1, Nicolae Valutsa2

  • 1Chemistry Department and AN Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, Russian Federation.

Archiv der Pharmazie
|February 11, 2026
PubMed
まとめ

ベルベリンの誘導体は,選択的に癌細胞の成長を抑制することを示しています. 最も効果的な化合物であるC9置換ベルベリンは,DNAにインターカレートすることによってナノモラー濃度で作用します.

キーワード:
ベルベリンのデリバティブサイト毒性 サイト毒性インターカレーション (intercalation) とは作用のメカニズム選択性の選択性とは

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