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Updated: Feb 12, 2026

Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions
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Palladium N-Heterocyclic Carbene Complexes: Synthesis from Benzimidazolium Salts and Catalytic Activity in Carbon-carbon Bond-forming Reactions

Published on: July 30, 2017

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ヘテロサイクル・イソステル・エクスプローラー:新型アロマティック・ヘテロサイクル・イソステルの発見のための計算ツール

Matthew T O Holland1,2, Víctor Sebastián-Pérez3, Anthony R Bradley4,5

  • 1Centre for Medicines Discovery, University of Oxford, NDM Research Building, Old Road Campus, Oxford OX3 7FZ, U.K.

Journal of medicinal chemistry
|February 11, 2026
PubMed
まとめ

新しい Python ツールである Heterocycle Isostere Explorer (HCIE) は,薬剤設計のための新しいヘテロサイクルのバイオアイソステルを特定しています. 3Dの類似性と物理化学的特性を用いて,新しい分子構造を示唆し,薬剤化学者を助けています.

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