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再発または耐火性肉腫の小児患者のゲムシタビン-ドクテキセル療法:単一センターでの経験
Metin Çil1, Begül Ganiye Yağcı1
1Division of Pediatric Hematology and Oncology, Department of Pediatrics, Adana City Training and Research Hospital, Ministry of Health, Adana, Türkiye.
Frontiers in pediatrics
|February 11, 2026
まとめ
ゲムシタビンとドセタキセル (GEMDOX) の組み合わせは,小児再発性/耐性肉腫に対する管理可能な安全性プロファイルを示しています. 反応率は控えめでしたが,治癒療法が限られている場合に緩和的な選択肢を提供します.
科学分野:
- 小児腫瘍学 小児腫瘍学
- 医療化学療法 化学療法
- サルコマ治療法 サルコマ治療法
背景:
- 小児性サーコマの予後は,限られた救済の選択肢があるため,貧弱です.
- ジェムシタビンとドセタキセル (GEMDOX) の組み合わせの有効性と毒性を評価する.
研究 の 目的:
- GEMDOXの有効性と安全性を,再発または耐火性肉腫の小児患者で評価する.
- 応答率,生存結果,および毒性プロフィールを決定します.
主な方法:
- GEMDOXで治療された36人の小児患者の遡及的分析.
- ゲムドックス療法:ゲムシタビン (1000 mg/m2 1日,8日) とドセタキセル (100 mg/m2 8日) を21日サイクルで投与する.
- 患者の平均年齢は13.5歳;最も一般的なのは骨肉腫 (58.3%).
主要な成果:
- 客観的応答率 (ORR) は5.8%,疾病制御率 (DCR) は14.6%でした.
- 平均進行性生存期 (PFS) は5.72ヶ月,平均全生存期 (OS) は12.33ヶ月でした.
- 最も一般的なグレード3〜4の毒性:ニュートロペニア (22.2%) と熱性ニュートロペニア (19.4%),G-CSFのサポートで管理できます. 治療に関連した死亡率はありません.
結論:
- GEMDOXは,重度の治療前の小児肉腫患者の管理可能な安全性プロファイルを持っています.
- 治癒の選択肢が限られている場合,管理可能な毒性を持つ実行可能な緩和的な選択肢を表します.
- 最適な有効性は,再発の設定で早期に達成されることがあります.
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