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Updated: Feb 12, 2026

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小児集団における頭蓋底手術-第2回国際共同研究(1995-2015)
Dan M Fliss1, Omer J Ungar2,3, Helena Levyn4
1Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel.
Head & neck
|February 11, 2026
まとめ
小児頭蓋底腫瘍に関するこの世界的レビューでは、肉腫が最も一般的であることがわかりました。陰性断端と補助放射線療法は生存を改善しましたが、硬膜浸潤は転帰を悪化させました。
科学分野:
- 小児腫瘍学;神経外科;頭蓋底腫瘍
背景:
- 小児の悪性頭蓋底腫瘍に関する世界的レビュー。 28施設から3061人の患者のデータ、うち64人が小児(2.1%)。
研究 の 目的:
- 小児頭蓋底悪性腫瘍の管理と転帰をレビューすること。 この集団における生存に影響を与える因子を特定すること。
主な方法:
- 臨床変数および生存転帰(OSおよびDFS)の遡及的分析。 予後因子を特定するための多変量解析。 開頭、内視鏡、および複合技術を含む外科的アプローチの評価。
主要な成果:
- 肉腫が最も頻度の高い悪性腫瘍(57.8%)であり、次いで嗅神経芽細胞腫(25.0%)、癌腫(17.2%)であった。 陰性手術断端の達成は、より良い転帰と関連していた(53.1%)。 硬膜浸潤は、全生存期間(OS)および無病生存期間(DFS)の低下と相関していた。補助放射線療法は生存を改善した。
結論:
- 開頭手術アプローチが一般的であったが、内視鏡技術は2015年までに増加した。 結果は、小児腫瘍学における内視鏡的頭蓋底手術の拡大使用を伴う過渡期を反映している。
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