肺転移切除術の長期成績
Michele Ferrari1, Camilla Valsecchi1, Giovanni Leuzzi1
1Division of Thoracic Surgery, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy.
Annals of surgical oncology
|February 11, 2026
まとめ
反復肺転移切除術は、肺転移を有する選択されたがん患者に対して治癒の可能性を提供する。本研究は、複数回および反復手術における長期的な実行可能性を示す。
科学分野:
- 胸部外科学、腫瘍外科、癌転移
背景:
- 肺転移はがん患者の最大30%に発生し、原発腫瘍の種類によって発生率は異なる。治療法の進歩により、肺転移切除術の範囲が広がっている。本研究では、反復肺転移切除術の長期予後と予後因子を検討する。
研究 の 目的:
- 肺転移切除術の長期予後を調査する。反復肺転移切除術の予後因子を特定する。複数回および反復手技の実行可能性と治癒の可能性を評価する。
主な方法:
- 1106人の患者における1503件の肺転移切除術(2003-2018年)の解析。単発転移(SM)、多発転移(MM)、再発転移(RM)コホートへの層別化。手術の種類と予後因子に焦点を当てる。
主要な成果:
- 10年生存率:全体で35.5%(単発転移41.1%、多発転移30.8%、再発転移31.1%)。中央生存期間は3.8年から5.9年の範囲。術後30日死亡率は0.1%。精密切除が最も一般的(53.2%)。
結論:
- 複数回および反復肺転移切除術は、慎重に選択された患者に対して実行可能である。これらの手技は、肺転移の管理において治癒の可能性を示す。長期生存データは、積極的な外科的管理の役割を支持する。
関連する概念動画
Long-term Depression
33.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
33.4K
Long-term Depression
3.4K
Long-term depression, or LTD, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTD is the process of synaptic weakening that occurs over time between pre and postsynaptic neuronal connections. The synaptic weakening of LTD works in opposition to synaptic strengthening by long-term potentiation (LTP) and together are the main mechanisms that underlie learning and memory.
Calcium Ion Concentration Mechanism
If over...
Calcium Ion Concentration Mechanism
If over...
3.4K
Multiple Allele Traits
38.2K
The Concept of Multiple Allelism
38.2K
Long-term Potentiation
58.8K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
58.8K
Long-term Potentiation
3.7K
Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when...
Hebbian LTP
LTP can occur when...
3.7K
Directional Terms
17.1K
Directional terms are essential for describing the relative locations of different body structures. For instance, an anatomist might describe one band of tissue as "inferior to" another, or a physician might describe a tumor as "superficial to" a deeper body structure. These terms often use comparative terms in pairs to trace out the relative locations of one body part to another or descriptions of body tissues like the deeper ones from superficially present with reference to...
17.1K


