関連する実験動画

Updated: Feb 12, 2026

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

Ex Vivo Treatment Response of Primary Tumors and/or Associated Metastases for Preclinical and Clinical Development of Therapeutics

Published on: October 2, 2014

消化器腫瘍治療のための開発中のTROP2標的療法

Jane E Rogers¹

¹U.T. M.D. Anderson Cancer Center Pharmacy Clinical Programs, Houston, TX, USA. jerogers@mdanderson.org.

Molecular diagnosis & therapy

|February 11, 2026

Abstract:

Overexpression of trophoblast cell surface antigen 2 (TROP2) has been identified in various malignancies. Antibody-drug conjugates (ADCs) targeting TROP2 with topoisomerase 1 inhibitor chemotherapy payloads are currently marketed in breast and lung cancer. TROP2 ADCs currently in use carry unique toxicities and come with specifics in supportive care therapy. TROP2 investigation is highly prevalent in current oncology, with multiple TROP2-targeting agents in the investigative pipeline for a vast array of malignancies. Combination strategies are also being explored. Gastrointestinal (GI) malignancies represent a heterogeneous group of cancers-with some of the most common malignancies and some with a high incidence of cancer-related deaths-in dire need of newer therapies. Early phase 1/2 data show a spark of activity in reports on colorectal cancer and gastroesophageal cancer. Studies are underway for targeting TROP2 in colorectal cancer, pancreatic cancer, biliary tract cancers, and gastroesophageal cancers. Discovering more targeted therapy in GI malignancies is of utmost importance. This review will focus on the current progress of TROP2-targeting therapies in GI investigations, and what lies ahead for the future.

キーワード:

TROP2 消化器がん抗体薬物複合体標的療法

さらに関連する動画

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

The Clinical Application of Tumor Treating Fields Therapy in Glioblastoma

Published on: April 16, 2019

関連する概念動画

Anatomy of the Gastrointestinal System

Anatomy of the Gastrointestinal System

The human digestive system is an intricate and essential network for nutrient absorption and waste elimination. It encompasses the gastrointestinal (GI) tract and several accessory organs.
Here's a detailed walkthrough of this complex system:

Gastrointestinal Motility Disorders

Gastrointestinal Motility Disorders

Gastrointestinal or GI motility disorders are characterized by irregular gastrointestinal tract movements, disrupting food transit from the mouth to the anus. They are caused by damage or dysfunction in gut muscles or nerves. These disorders can cause symptoms such as severe constipation, diarrhea, abdominal pain, and swallowing difficulties. Disorders can affect any segment of the GI tract and range widely in severity, from common conditions like GERD to life-threatening conditions like...

Histology of the Gastrointestinal (GI) Tract

Histology of the Gastrointestinal (GI) Tract

The GI tract, from beginning to end, is made up of four continuous tissue layers that adjust their structure according to their specific roles. These layers, from innermost to outermost, are known as the mucosa, submucosa, muscularis, and serosa, which are continuous with the mesentery.
The mucosa is sometimes called a mucous membrane due to its mucus-secreting features. This membrane is composed of epithelium, which directly interacts with ingested substances, and the lamina propria, a layer...

Therapeutic Index

Therapeutic Index

The therapeutic index of a drug is a key parameter in pharmacology that quantifies the relative safety of a drug by calculating the ratio between the dose that causes toxicity in half the population (50%) to the dose that proves to be effective for half the population (50%). It provides a spectrum of doses for a particular drug ranging from effective to potentially toxic. To illustrate, consider an anticoagulant agent like warfarin. It possesses a narrow window within its therapeutic index to...

Physiology of the Gastrointestinal System I: Ingestion and Propulsion

Physiology of the Gastrointestinal System I: Ingestion and Propulsion

The physiology of the gastrointestinal system begins with ingestion as food enters the mouth.

Physiology of the Gastrointestinal System II: Digestion and Absorption

Physiology of the Gastrointestinal System II: Digestion and Absorption

The gastrointestinal (GI) tract, extending from the mouth to the anus, plays a pivotal role in the digestion and absorption of nutrients. This process involves both mechanical and chemical actions facilitated by various enzymes.
Digestion begins in the mouth, where food undergoes mechanical breakdown by chewing and combines with saliva. Salivary amylase, an enzyme in saliva, starts the breakdown of starches into maltose. The food then travels down the esophagus to the stomach.
In the stomach, a...