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Updated: Feb 12, 2026

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Lumped-Parameter and Finite Element Modeling of Heart Failure with Preserved Ejection Fraction

Published on: February 13, 2021

左室駆出率が保たれた心不全患者における心房性機能性僧帽弁逆流に対するリズムコントロールの価値

A F Safarova¹, Zh D Kobalava¹, S B Adam¹

¹Patrice Lumumba Peoples' Friendship University of Russia (RUDN University), Moscow.

|February 11, 2026

要旨

Aim:

To assess the incidence, severity, and predictors of functional atrial mitral regurgitation (FAMR) and its impact on outcomes in patients with heart failure with preserved ejection fraction (HFpEF) depending on the presence of atrial fibrillation (AF).

Material And Methods:

Data from 218 patients with HFpEF and FAMR hospitalized between 2020 and 2023 were analyzed retrospectively. The median follow-up period was 589 days.

Endpoints:

rehospitalization for heart failure (HF), cardiovascular death (CVD), and the composite endpoint (CE).

Results:

Moderate FAMR was detected in 53.3% of patients with AF, and severe FAMR in 15.3%, which was significantly higher than the incidence in patients with sinus rhythm (SR) (24.5% and 8.0%, respectively, p<0.001). In the subgroup with AF, severe FAMR was associated with a 4.1-fold increased risk of rehospitalization for HF (95% confidence interval (CI): 1.7-10.2, p=0.002) and a 2.6-fold increased risk of CE (95% CI: 1.4-4.9, p=0.002). In patients with SR, no statistically significant association between FAMR and clinical outcomes was found.

Conclusion:

FAMR in AF is an independent predictor of poor prognosis in patients with HFpEF. This highlights the importance of rhythm control as a pathogenetic strategy for this patient category.

キーワード:

心房細動心不全僧帽弁逆流リズムコントロール予後

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An Image Guided Transapical Mitral Valve Leaflet Puncture Model of Controlled Volume Overload from Mitral Regurgitation in the Rat

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Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

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Published on: July 20, 2022

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