Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Histone Variants at the Centromere02:30

Histone Variants at the Centromere

5.1K
Histone variants are the histone proteins with structural and sequence variations. These variants may be regarded as “mutant” forms that replace their canonical histone counterparts in the nucleosomes. Specific post-translational modifications on the histone variants enable further chromatin complexity and regulate tissue-specific gene expression. The most common histone variants are from histone H2A, H2B, and linker histone H1 families. However, several variants of histone H3...
5.1K
Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

7.6K
Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
7.6K
Integration by Parts: Indefinite Integrals01:26

Integration by Parts: Indefinite Integrals

230
Integration by parts is a fundamental technique in calculus for evaluating integrals involving the product of two functions. It is particularly useful when direct integration is not feasible. The method is based on the product rule for differentiation, which states that the derivative of a product equals the derivative of the first function times the second, plus the first function times the derivative of the second. By integrating this identity and rearranging terms, the integration by parts...
230
Integration by Parts: Definite Integrals01:23

Integration by Parts: Definite Integrals

92
Definite integrals involving the product of two functions over a fixed interval can be evaluated using integration by parts. This method rewrites the integral as the difference of a product evaluated at the endpoints and a remaining definite integral that is often simpler to compute.A representative example is the definite integral of the inverse tangent function. Since there is no direct integration formula for arctan ⁡x, the integrand is rewritten as a product of arctan⁡ x and the...
92
Computed Tomography01:10

Computed Tomography

8.9K
Tomography refers to imaging by sections. Computed tomography (CT) is a non-invasive imaging technique that uses computers to analyze several cross-sectional X-rays to reveal minute details about structures in the body.
The technique was invented in the 1970s and is based on the principle that as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates...
8.9K
Dynamic Equilibrium02:20

Dynamic Equilibrium

63.4K
A reversible chemical reaction represents a chemical process that proceeds in both forward (left to right) and reverse (right to left) directions. When the rates of the forward and reverse reactions are equal, the concentrations of the reactant and product species remain constant over time and the system is at equilibrium. A special double arrow is used to emphasize the reversible nature of the reaction. The relative concentrations of reactants and products in equilibrium systems vary greatly;...
63.4K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Correction: Basit et al. Brassinosteroid Supplementation Alleviates Chromium Toxicity in Soybean (<i>Glycine max</i> L.) via Reducing Its Translocation. <i>Plants</i> 2022, <i>11</i>, 2292.

Plants (Basel, Switzerland)·2026
Same author

Successful Management of Severe Hypertriglyceridemia Presenting With Eruptive Xanthomas as an Outpatient Without Development of Acute Pancreatitis: A Case Report.

Cureus·2026
Same author

Anticancer potential of geranyl acetate through RelA gene downregulation in acute myeloid leukemia cells.

Scientific reports·2026
Same author

Population pharmacokinetics and resistance patterns of vancomycin and amikacin in pediatric oncology patients.

Drug metabolism and disposition: the biological fate of chemicals·2026
Same author

Volatile versus intravenous anesthesia and postoperative neurocognition: A meta-analysis and trial-sequential analysis.

Journal of clinical anesthesia·2026
Same author

Retraction notice to 'Hydrogeochemical properties, source provenance, distribution, and health risk of high fluoride groundwater: Geochemical control, and source apportionment' [Environ. Pollut. 362, (2024) 125000].

Environmental pollution (Barking, Essex : 1987)·2026

関連する実験動画

Updated: Feb 13, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K

構造とダイナミクスを破壊する病原性KRASバリアント：統合計算解析からの洞察

Saqib Ishaq1,2,3, Aizaz Ali4, Obaid Habib1

  • 1Guangdong Provincial Key Laboratory of System Biology and Synthetics Biology for Urogenital Tumors, School of Basic Medicine, Shenzhen University Medical School, Shenzhen University (SZU), Shenzhen, Guangdong, China.

PloS one
|February 11, 2026
PubMed
まとめ

計算解析により、タンパク質構造を不安定化させる4つの有害なKRAS遺伝子バリアント（L79P、A130P、G138E、F141L）が特定され、大腸がんや肺がんなどの癌における発がん活性化を促進する可能性がある。

キーワード:
KRAS癌計算解析構造ダイナミクス変異発がん活性化

さらに関連する動画

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

1.3K
Advanced Self-Healing Asphalt Reinforced by Graphene Structures: An Atomistic Insight
08:03

Advanced Self-Healing Asphalt Reinforced by Graphene Structures: An Atomistic Insight

Published on: May 31, 2022

5.7K

関連する実験動画

Last Updated: Feb 13, 2026

Following the Dynamics of Structural Variants in Experimentally Evolved Populations
04:52

Following the Dynamics of Structural Variants in Experimentally Evolved Populations

Published on: February 3, 2023

1.4K
Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis
08:49

Incorporating Target Protein Structure Flexibility and Dynamics in Computational Drug Discovery Using Ensemble-Based Docking Analysis

Published on: June 20, 2025

1.3K
Advanced Self-Healing Asphalt Reinforced by Graphene Structures: An Atomistic Insight
08:03

Advanced Self-Healing Asphalt Reinforced by Graphene Structures: An Atomistic Insight

Published on: May 31, 2022

5.7K

科学分野:

  • がんゲノム学
  • 計算生物学
  • 構造生物学

背景:

  • KRASは、膵臓癌、大腸癌、肺癌で頻繁に変異するがん遺伝子です。
  • KRASバリアントが機能を変えるメカニズムはほとんど理解されていません。
  • この研究では、KRASにおける有害な非同義一塩基多型（nsSNP）の特定に焦点を当てています。

研究 の 目的:

  • 病原性KRAS nsSNPを特定し、特徴づけること。
  • KRAS構造、安定性、および発がん性に対するこれらのバリアントの原子レベルの影響を解明すること。

主な方法:

  • 統合計算ワークフローを使用して173のnsSNPをスクリーニングしました。
  • 病原性予測、進化的な保存性、構造モデリング、分子ドッキング、および分子動力学シミュレーションを採用しました。
  • 翻訳後修飾とタンパク質間相互作用を評価しました。

主要な成果:

  • 4つの高影響の有害なバリアント、L79P、A130P、G138E、およびF141Lを特定しました。
  • シミュレーションにより、これらのバリアントがコンフォメーション安定性、残基の柔軟性、および結合エネルギーを摂動させることが示されました。
  • バリアントは大腸癌、膵臓癌、肺癌に関連しており、臨床的関連性を示唆しています。

結論:

  • 発がん活性化を駆動するKRASバリアントのメカニズムに関する洞察を提供します。
  • 特定されたバリアントは、実験的検証のための最優先ターゲットです。
  • 癌生物学研究における計算手法の有用性を強調しています。