トルコ成人における日常生化学検査の参照基準値の検証：reflimRの使用
Levent Deniz1, Ozlem Demirelce2
1Department of Medical Biochemistry, University of Health Sciences Türkiye, Istanbul Training and Research Hospital, Istanbul, Türkiye.
PloS one
|February 11, 2026
まとめ
本研究では、reflimR法を用いてトルコ人成人の参照基準値（RI）を検証し、集団の違いにより製造元のRIとの乖離が見られた。reflimRアルゴリズムは、RIの計算と検証にアクセス可能な方法を提供する。
科学分野:
- 臨床生化学; 検査医学; 公衆衛生
背景:
- 正確な参照基準値（RI）の確立は、臨床検査結果の解釈に不可欠である。; 製造元提供のRIは、多様な集団を正確に反映していない可能性があり、地域的な検証が必要である。; reflimR法は、間接RI推定および検証のための新しいアプローチを提供する。
研究 の 目的:
- トルコ人成人集団における19項目の日常生化学検査の参照基準値（RI）を検証する。; reflimR法を用いて導出されたRIと製造元提供のRIを比較する。; reflimRアルゴリズムの性能を他の間接RI推定法と比較評価する。
主な方法:
- Beckman Coulterアナライザーで分析された19項目の生化学パラメータのRIを評価するためにreflimRアルゴリズムを利用した。; 男性および女性のRI推定のために、5つの間接アプローチ（reflimR、refineR、KOSMIC、Hoffmann、Bhattacharya）を採用した。; RI限界検証のために、許容不確実性に基づくトラフィックライトアルゴリズムを適用した。
主要な成果:
- reflimRによって計算された76のRI限界のうち40が受理され、21は確認が必要で、15は製造元の値と比較して却下された。; reflimR法は、ALT、GGT、総ビリルビンを除き、他の間接法と一般的に一致した結果を示した。; 検証の失敗は、集団間の民族、性別、年齢、地理的な変動の可能性を浮き彫りにした。
結論:
- reflimRアルゴリズムは、RIの計算と検証のための迅速かつアクセス可能なツールを提供する。; RIの乖離は、集団特異的な検証の重要性を強調する。; 民族性や人口統計などの要因は、RIの確立に大きく影響する。
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