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Updated: Feb 13, 2026

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells

Generation of Prostate Cancer Patient Derived Xenograft Models from Circulating Tumor Cells

Published on: October 20, 2015

前立腺がんに対する炭素イオン線放射線療法における酸素効果を考慮した腫瘍制御確率解析

Yushi Wakisaka¹, Shuka Fukuda², Toshiro Tsubouchi³

¹Medical Physics Laboratory, Division of Health Science, Graduate School of Medicine, The University of Osaka, Osaka, Japan.

Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB)

|February 11, 2026

要旨

Purpose:

Carbon ion radiotherapy (CIRT) is expected to be effective against hypoxic tumors due to its lower oxygen enhancement ratio (OER) compared to X-ray radiotherapy (XRT). OER is expected to have a significant impact on therapeutic efficacy, especially for prostate cancer, which has low oxygen partial pressure. This study aimed to derive OERs for photon and carbon-ion spread-out Bragg peak (SOBP) irradiation through cellular experiments and incorporate them into the tumor control probability (TCP) function to test consistency with clinical outcomes.

Methods:

To derive the OER for photons and the OERs at three depths (proximal, center, and distal) within the carbon-ion SOBP, the dose-dependent survival rate of the prostate cancer cell line PC3 was measured under both aerobic and hypoxic conditions. TCP functions incorporating dose-dependent OERs based on clinical prescription doses were fitted to clinical outcomes of prostate cancer treated with XRT and CIRT to test the clinical relevance of the obtained OERs.

Results:

The OERs at 10% survival for PC3 cells were 2.12 ± 0.68 for photons, and 1.70 ± 0.13, 1.65 ± 0.19, and 1.56 ± 0.13 at the proximal, center, and distal depths of the carbon-ion SOBP, respectively. The TCP functions calculated using dose-dependent OERs were not inconsistent with the clinical outcomes for both XRT and CIRT, supporting the clinical relevance of the OERs derived from cell experiments.

Conclusion:

The carbon-ion SOBP used in prostate cancer treatment has a lower OER than photons, suggesting its potential effectiveness against hypoxic tumors.

キーワード:

炭素イオン線療法酸素増強比前立腺がん腫瘍制御確率

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Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer

Generation of Tumor Organoids from Genetically Engineered Mouse Models of Prostate Cancer

Published on: June 13, 2019

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Isolation of Cancer Stem Cells From Human Prostate Cancer Samples

Published on: March 14, 2014

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