関連する実験動画

Updated: Feb 13, 2026

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Author Spotlight: Integrating Alveolar-Capillary Reserve Measurements in Exercise Adaptation and Therapeutic Strategies

Published on: February 2, 2024

単回呼気法による一酸化炭素の肺拡散能評価におけるDLCOおよびKCOの重要指標

Masafumi Yamamoto¹, Masaharu Nishimura², Kaoruko Shimizu³

¹Division of Laboratory and Transfusion Medicine, Hokkaido University Hospital, North 14 West 5, Kita-ku, Sapporo, 060-8648, Japan.

Respiratory investigation

|February 11, 2026

Abstract:

The measurement of diffusing capacity of the lung for carbon monoxide (DL_CO) is an invaluable pulmonary function test for assessing gas exchange in the lungs. Typically, the test is conducted via the single-breath method, wherein after maximum inhalation of carbon monoxide and helium simultaneously, the breath is held for 10 s. The test provides the single value of DL_CO, and sometimes, the DL_CO corrected by alveolar volume (V_A) at the measurement. However, DL_CO is the product of two independent components in reality-the transfer coefficient for carbon monoxide (K_CO) and V_A. Conventionally, K_CO has often been expressed as DL_CO/V_A. In this report, we will demonstrate the change in relationship of DL_CO with K_CO uniquely and characteristically due to emphysema, fibrosis, and their combined disease. Therefore, the assessment of both indices is highly desirable in the precise interpretation of the test. The term "K_CO" is preferable to DL_CO/V_A to avoid misleading.

キーワード:

肺胞気量 DL(CO)肺気腫線維症 K(CO)

さらに関連する動画

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Assessment of Pulmonary Capillary Blood Volume, Membrane Diffusing Capacity, and Intrapulmonary Arteriovenous Anastomoses During Exercise

Published on: February 20, 2017

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Phenotyping Mouse Pulmonary Function In Vivo with the Lung Diffusing Capacity

Published on: January 6, 2015

関連する概念動画

Lung Capacity

Lung Capacity

The air in the lungs is measured in volumes and capacities. Lung volume measures reflect the amount of air taken in, released, or left over after a lung function, like a single inhalation. Lung capacity measures are sums of two or more lung volume measures.

Indicators

Indicators

Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...

Breathing

Breathing

The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...

Respiratory Assessment: Purpose and Indications

Respiratory Assessment: Purpose and Indications

Respiratory assessment is a cornerstone of nursing assessments, crucial for the early detection of patient deterioration. This evaluation transcends routine procedures, representing a critical skill nurses must master to ensure optimal patient care.
Objectives and Importance:
The primary goal of respiratory assessment is to evaluate patients at early risk of clinical deterioration. Since respiratory distress often precedes other signs of declining health, breathing patterns and sounds become a...

Assessment of Diffusion and Perfusion

Assessment of Diffusion and Perfusion

Understanding and evaluating diffusion and perfusion is critical in assessing a patient's respiratory and circulatory health. These processes play key roles in maintaining the body's internal environment, ensuring that tissues receive adequate oxygen while waste products are efficiently removed.
The Role of Diffusion in Respiration
Diffusion is the process by which molecules move from an area of higher concentration to an area of lower concentration. In the respiratory system, this...

Diffusion

Diffusion

Diffusion is the passive movement of substances down their concentration gradients—requiring no expenditure of cellular energy. Substances, such as molecules or ions, diffuse from an area of high concentration to an area of low concentration in the cytosol or across membranes. Eventually, the concentration will even out, with the substance moving randomly but causing no net change in concentration. Such a state is called dynamic equilibrium, which is essential for maintaining overall...