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Updated: Feb 13, 2026

Obtaining Human Microglia from Adult Human Brain Tissue

Obtaining Human Microglia from Adult Human Brain Tissue

Published on: August 30, 2020

ミクログリアの変身：オンデマンド制御パネルの改造

Takahiro Masuda¹

¹Division of Molecular Neuroimmunology, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan.

|February 11, 2026

Abstract:

Microglia display remarkable plasticity, with their cellular states evolving in response to developmental stage, regional context, and environmental or pathological stimuli. In this issue of Immunity, Hamagami et al. demonstrate that adaptive reconfiguration of regulatory networks, particularly the dynamics of enhancers, underlies these state transitions. Conserved enhancers link developmental and Alzheimer's-related microglial states, suggesting shared epigenetic frameworks that influence neurodegenerative susceptibility.

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Published on: October 3, 2019

Generation of Human Microglia to Combine Them with Retinal Organoids for Improved Disease Modeling

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Published on: July 26, 2024

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