悪性遠位胆道閉鎖に対する抗移動型 vs. 従来の完全被覆型自己拡張型金属ステントの比較:単一施設長期研究
Emmanuel Palomera-Tejeda1, Fares Ayoub1, Tara Keihanian1
1Department of Gastroenterology and Hepatology, Baylor College of Medicine, Houston TX; Baylor St. Luke's Medical Center - Houston, TX.
Background & Aims:
Fully covered self-expandable metal stents (FCSEMSs) palliate distal malignant biliary obstruction (dMBO), but migration remains a limitation. We compared a finned anti-migration FCSEMS (AMS) with a conventional flared FCSEMS (CS).
Methods:
Retrospective cohort (April 2020-April 2024) of adults with unresectable dMBO undergoing ERCP with AMS or CS. Primary outcomes were stent migration and recurrent biliary obstruction (RBO). Time-to-event outcomes were analyzed using IPTW Cox models, with PSM for sensitivity.
Results:
Among 276 patients (CS 172; AMS 104), crude migration was lower with AMS (0.96% vs 7.6%; p=0.02). After IPTW adjustment, migration risk remained directionally lower but was not statistically significant (HR 0.23; 95% CI 0.03-1.80; p=0.16). Migration remained numerically lower after PSM (p=0.10). RBO risk was similar across groups.
Conclusions:
Anti-migration FCSEMSs demonstrated lower crude migration with similar patency (RBO risk), but adjusted analyses did not reach statistical significance.
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