慢性失語症におけるネットワークレベルの構造的および機能的切断に関連する一貫した白質病変

Yuki Kumagae¹, Atsushi Yamaguchi¹

¹Department of Functional Anatomy, Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan.

Neuroscience

|February 11, 2026

まとめ

失語症は、皮質損傷だけでなく、特定の白質病変に関連しています。この限局性の病変は、広範な構造的および機能的切断を引き起こし、言語ネットワークに影響を与えます。

科学分野:

神経科学
神経学
神経画像

背景:

失語症は伝統的に、失語症領域における皮質損傷に関連付けられてきました。
失語症におけるより広範なネットワークレベルの機能不全を示唆するエビデンスが登場しています。

研究の目的:

失語症における一貫した白質病変を調査すること。
構造的機能不全（SDC）を機能的ネットワークの破壊および重症度に関連付けること。

主な方法:

慢性失語症患者58例におけるマルチモーダルMRI解析。
ボクセルベース病変オーバーラップマッピング（VLOM）および病変症状マッピング（VLSM）。
拡散線維走行再構成およびネットワークモデリング。

主要な成果:

左中心溝下の限局性白質病変は、患者の90％に見られました。
この病変は、失語症を他のタイプと区別しました（OR=149.2、p<0.001）。
SDCは、広範な機能的機能不全および言語障害と相関していました（r>0.4、p<0.05）。

結論:

失語症は、一貫した限局性白質病変に由来します。
この病変は、分布した構造的および機能的切断を引き起こします。
病理は失語症領域を超えて広がり、大規模な脳ネットワークに影響を与えます。

キーワード:

失語症線維走行再構成 VLSM fMRI

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