原発性肛門直腸悪性黒色腫の診断および低侵襲治療的切除法としての内視鏡的粘膜下層剥離術

Primary anorectal malignant melanoma is a rare mucosal malignancy with nonspecific symptoms, frequent misdiagnoses, delayed treatment, and the lack of an established standard therapeutic strategy are the reasons for a poor prognosis. Diagnostic challenges are further compounded by the low rate of preoperative histological confirmation, especially for amelanotic lesions. Given its poor prognosis, performing a less invasive resection is crucial. We herein report the case of an 82-year-old male patient who underwent endoscopic submucosal dissection as a total biopsy and was treated with immune checkpoint inhibitors as adjuvant therapy.