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Updated: Feb 13, 2026

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Orthotopic Ovarian Transplantation Procedures to Investigate the Life- and Health-span Influence of Ovarian Senescence in Female Mice

Published on: February 12, 2018

心血管健康のためのライフコースアプローチによる周産期予防

Hooi Min Lim¹, Darwin R Labarthe²

¹Department of Primary Care Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia hmlim@um.edu.my.

Heart (British Cardiac Society)

|February 11, 2026

Abstract:

Primordial prevention is the strategy of preventing occurrence of cardiovascular risk factors from early life and promoting favourable life course trajectories of cardiovascular health. While the term 'primordial prevention' was introduced by Strasser in 1978, representing a society-wide strategy to prevent epidemics of cardiovascular risk factors, the concept has been implemented far less to date than is needed to reduce the global cardiovascular burden. The primary purpose of this review is to increase understanding of the concept and strategy of primordial prevention for reducing the burden of cardiovascular disease and its relation to cardiovascular health. We discuss the influence of upstream adverse social and structural determinants on the development of traditional cardiovascular risk throughout the life course. We summarise recent trial evidence of intervention effectiveness and highlight policy and practice opportunities that can achieve the potential of primordial prevention as a sustainable and equitable strategy for promoting cardiovascular health across the life course.

キーワード:

心血管疾患グローバルヘルスリスク要因

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