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Chromatin Position Affects Gene Expression02:35

Chromatin Position Affects Gene Expression

24.9K
Chromatin is the massive complex of DNA and proteins packaged inside the nucleus. The complexity of chromatin folding and how it is packaged inside the nucleus greatly influences  access to genetic information. Generally, the nucleus' periphery is considered transcriptionally repressive, while the cell's interior is considered a transcriptionally active area. 
Topologically Associated Domains (TADs)
The 3-dimensional positioning of chromatin in the nucleus influences the...
24.9K
What is Gene Expression?01:42

What is Gene Expression?

197.1K
Overview
Gene expression is the process in which DNA directs the synthesis of functional products, that is, proteins. Cells can regulate gene expression at various stages. It allows organisms to generate different cell types and enables cells to adapt to internal and external factors.
Genetic Information Flows from DNA to RNA to Protein
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is made up of nucleotides and proteins consist of amino...
197.1K
What is Gene Expression?01:36

What is Gene Expression?

11.6K
A gene is a stretch of DNA that serves as the blueprint for functional RNAs and proteins. Since DNA is comprised  of nucleotides and proteins are comprised of amino acids, a mediator is required to convert the information encoded in DNA into proteins. This mediator is the messenger RNA (mRNA). mRNA copies the blueprint from DNA by a process called transcription. In eukaryotes, transcription occurs in the nucleus by complementary base-pairing with the DNA template. The mRNA is then...
11.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

5.6K
5.6K
mRNA Stability and Gene Expression02:51

mRNA Stability and Gene Expression

6.7K
The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
6.7K

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Updated: Feb 13, 2026

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
11:52

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

6.5K

PreTSA:時的および空間的な遺伝子発現パターンの計算効率の良いモデリング.

Haotian Zhuang1, Zhicheng Ji2

  • 1Department of Biostatistics and Bioinformatics, Duke University School of Medicine, Durham, NC, USA.

Genome biology
|February 12, 2026
PubMed
まとめ
この要約は機械生成です。

PreTSAは,単細胞と空間トランスクリプトミクスの大規模なデータセットにおける遺伝子発現パターンを分析するための効率的な計算方法である. PreTSAは既存の方法と一致しています.

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Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants
08:33

Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants

Published on: August 5, 2020

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Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency
12:55

Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency

Published on: January 7, 2010

24.8K

関連する実験動画

Last Updated: Feb 13, 2026

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps
11:52

Temporal Ordering of Dynamic Expression Data from Detailed Spatial Expression Maps

Published on: February 9, 2017

6.5K
Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants
08:33

Laser-Capture Microdissection RNA-Sequencing for Spatial and Temporal Tissue-Specific Gene Expression Analysis in Plants

Published on: August 5, 2020

8.8K
Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency
12:55

Using the Gene Pulser MXcell Electroporation System to Transfect Primary Cells with High Efficiency

Published on: January 7, 2010

24.8K

科学分野:

  • 計算生物学とは,計算生物学である.
  • ゲノミクスゲノミクスとは
  • バイオインフォマティックス

背景:

  • 遺伝子発現パターンのための大規模な単細胞と空間トランスクリプトミクスのデータを分析することは,計算的に要求されています.
  • 現存する方法は,現代のトランスクリプトミックのデータセットの規模と格闘し,生物学的洞察を制限しています.

研究 の 目的:

  • 時間的および空間的な遺伝子発現パターンをモデリングするための計算効率の良い方法であるPreTSAを導入する.
  • 数百万個の細胞を含む,大規模な単細胞および空間トランスクリプトミクスデータにPreTSAの適用性を実証する.

主な方法:

  • 新しい計算手法であるPreTSAの開発.
  • PreTSAの適用は,単細胞と空間トランスクリプトミクスのデータセットのサイズによって異なります.

主要な成果:

  • PreTSAは,最先端の方法と比較して計算時間を大幅に短縮します.
  • PreTSAは,遺伝子発現パターンのモデリングにおいて,既存の方法と比較できる結果を達成しています.
  • PreTSAは,数百万個のセルを含むデータセットのスケーラビリティを証明しています.

結論:

  • PreTSAは,大規模なトランスクリプトミクスデータを分析するための計算効率の高いソリューションを提供します.
  • この方法は,前例のない大規模なデータセットでの遺伝子発現パターンの研究を可能にします.
  • PreTSAは,単細胞と空間トランスクリプトミクスからのより深い生物学的洞察を容易にする.