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高齢患者のセフトリアクソン関連肝機能不全のリスク因子分析
Tomohiko Tagashira1, Ryoya Odawara2, Naohito Suga2
1Department of Pharmacy, Innoshima-Ishikai Hospital, 1962 Nakanosho-cho, Innoshima, Onomichi-shi, Hiroshima, Japan. bcxpc0252000@yahoo.co.jp.
Journal of pharmaceutical health care and sciences
|February 12, 2026
まとめ
ベースラインのアラニンアミノトランスフェラーゼ (ALT) とC反応性タンパク質 (CRP) のレベルが上昇すると,高齢者のセフトリアキソン (CTRX) に関連した肝臓機能障害のリスクが増加します. 肝機能のモニタリングは,この集団にとって極めて重要です.
科学分野:
- 薬理学 薬理学とは
- 肝臓病理学 肝臓病理学
- ゲリアトリクス ゲリアトリクス
背景:
- 高齢患者のセフトリアキソン (CTRX) 誘発性肝損傷に関するデータは限られている.
- この研究は,65歳以上の個体において,CTRXに関連した肝機能不全の危険因子を特定することを目的とした.
研究 の 目的:
- 65歳以上の患者でセフトリアクソンに関連した肝機能障害の危険因子を調査する.
- 特定されたリスク要因の最適なカットオフ値を設定する.
主な方法:
- CTRX.を投与された65歳以上の入院患者105人のレトロスペクティブチャートレビュー.
- 単変数および多変数ロジスティック回帰分析を使用して,独立したリスク要因を特定しました.
- 受信器の動作特性 (ROC) 曲線解析により,アラニンアミノトランスフェラーゼ (ALT) とC反応性タンパク質 (CRP) の最適なカットオフ値が決定されました.
主要な成果:
- ALT (≥11 U/L) とCRP (≥5.9 mg/dL) の上昇は,単変数解析では肝機能不全と有意に関連していた.
- 多変量分析により,ALT (OR 1.14) とCRP (OR 1.07) が独立した危険因子であると確認されました.
- ALTとCRPの両方が上昇した患者は,肝機能不全の発生率が50%であり,他のグループよりも著しく高かった (p<0.001).
結論:
- ALTとCRPの基準値の上昇は,高齢者のCTRX誘発性肝機能不全のリスクの増加と関連しています.
- この研究では,この集団において,CTRXの投与中およびその後,肝機能の注意深いモニタリングを推奨しています.
- ALTまたはCRPが上昇した患者を特定することは,CTRX関連肝損傷を予測し,潜在的に予防するのに役立ちます.
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