Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Nucleic Acids02:43

Nucleic Acids

50.7K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
50.7K
Nucleic acids02:43

Nucleic acids

190.9K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and carry instructions for its functioning.
DNA and RNA
The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA). DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and in the organelles, chloroplasts, and mitochondria. In prokaryotes,...
190.9K
Nucleic Acids02:43

Nucleic Acids

9.0K
9.0K
Nucleic Acid Structure01:25

Nucleic Acid Structure

9.5K
The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
DNA Structure
DNA...
9.5K
Nucleic Acids and Nucleotides01:20

Nucleic Acids and Nucleotides

15.2K
Nucleic acids are the most important macromolecules for the continuity of life. They carry the cell's genetic blueprint and have instructions for its functioning. The two main types of nucleic acids are deoxyribonucleic acid (DNA) and ribonucleic acid (RNA).
Deoxyribonucleic Acid (DNA)
DNA is the genetic material in all living organisms, ranging from single-celled bacteria to multicellular mammals. It is in the nucleus of eukaryotes and the organelles such as chloroplasts and mitochondria....
15.2K
Biosynthesis of Nucleic Acids01:28

Biosynthesis of Nucleic Acids

1.2K
Nucleic acid biosynthesis is a fundamental biochemical process that produces the purine and pyrimidine nucleotides essential for DNA and RNA synthesis. This pathway maintains a balanced nucleotide pool, preventing imbalances that could jeopardize genetic integrity and cellular function. Given the crucial role of nucleotides, their synthesis is tightly regulated to ensure proper cellular homeostasis.Purine BiosynthesisThe biosynthesis of purine nucleotides begins with ribose-5-phosphate, a...
1.2K

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

Drug-Conjugated Tam-NHC-Gold(I) Complexes Overcome <i>ESR1</i> Mutant Breast Cancer Resistance and Downregulate the RAMP3/CALCR Signaling Pathway.

Journal of medicinal chemistry·2026
Same author

Hepatitis C virus inhibits the E2F2/PI3K/AKT signaling pathway through miR-378b and leads to glycolipid metabolism disorders in the liver.

Molecular biology reports·2026
Same author

Learning Occlusion-Dynamic Invariant Representations for Multi-Object Tracking.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2026
Same author

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Discovery of NTQ2494, a potent and orally bioavailable inhibitor of AXL kinase for the treatment of human tumors.

European journal of medicinal chemistry·2026
Same author

Data-Driven Interrogation of Reactivity in Acid-Catalyzed Carbonyl-Olefin Metathesis with Machine Learning and Large Language Models.

Journal of the American Chemical Society·2026

関連する実験動画

Updated: Feb 13, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
06:52

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

8.8K

スマートDNAヒドロゲル反応型エンコーディングは,携帯型核酸検出を可能にします.

Jie Luo, Yu Tang, Hongzhao Yang

  • 1Department of Biological and Environmental Engineering, Cornell University, Ithaca NY14853-5701, United States.

ACS nano
|February 12, 2026
PubMed
まとめ

Q-RAPIDという新しいDNAヒドロゲルプラットフォームは,迅速で携帯可能な核酸検出を可能にします. このバイオセンシングデバイスは,病原体を特定するための高い精度を提供し,さまざまな医療環境での診断を強化します.

キーワード:
DNAヒドロゲルDNAヒドロゲルインテリジェント・デジタル・アナリスト核酸検出 核酸検出紙ベースの微流体材料ポイント・オブ・ケア・テスト

さらに関連する動画

Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

7.8K
Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
13:15

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

34.7K

関連する実験動画

Last Updated: Feb 13, 2026

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
06:52

Kinetic Screening of Nuclease Activity using Nucleic Acid Probes

Published on: November 1, 2019

8.8K
Visual Detection of Multiple Nucleic Acids in a Capillary Array
08:56

Visual Detection of Multiple Nucleic Acids in a Capillary Array

Published on: November 15, 2017

7.8K
Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
13:15

Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules

Published on: June 1, 2011

34.7K

科学分野:

  • バイオマテリアル科学 バイオマテリアル科学
  • 分子診断は分子診断です.
  • バイオセンシング技術

背景:

  • DNAヒドロゲルはバイオセンシングの可能性を示しているが,拡散が遅いため,体積が大きいため,ポータブル診断では課題に直面している.
  • 現在の方法は,ケアポイントでの応用のために,迅速で正確でアクセシブルな核酸検出が欠けている.

研究 の 目的:

  • 迅速かつ携帯可能な核酸検出のためのスマートなDNAヒドロゲル反応センサープラットフォームQ-RAPIDを開発する.
  • 既存のDNAヒドロゲルバイオセンサの限界を克服し,ターゲット配信,信号増幅,データ出力を改善します.

主な方法:

  • Q-RAPIDは,毛細血管駆動型輸送用の紙製の支架,DNAハイブリッド化と鎖移位のためのヒドロゲルセンシングモジュール,デジタルQRコードの出力を統合しています.
  • このシステムは,視覚信号の増幅のために,標的特異のDNAハイブリッド化によって誘発される色測定反応を利用しています.
  • スマートフォンの統合により,自動分類と結果の無線報告が可能になります.

主要な成果:

  • Q-RAPIDは,標的核酸の検出において高い性能を示し,91%の感度と97.3%の精度を達成しました.
  • ウイルスの擬似ウイルスモデルと100個の臨床標本による検査は95%の一致を示した.
  • プラットフォームの設計は,さまざまな呼吸器系病原体を検出するために再構成可能です.

結論:

  • Q-RAPIDは,携帯型核酸検出のための有望なソリューションを提供し,現在のDNAヒドロゲルバイオセンサの主要な制限を克服します.
  • プラットフォームの精度,速度,使いやすさは,リソースが限られた環境を含む多様な医療環境でのアプリケーションをサポートします.
  • この技術は,迅速な分子診断の範囲を拡大する可能性を秘めています.