関連する実験動画

Updated: Feb 13, 2026

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028
09:08

From a Natural Product to Its Biosynthetic Gene Cluster: A Demonstration Using Polyketomycin from Streptomyces diastatochromogenes Tü6028

Published on: January 13, 2017

17.8K

直接経路合成および編集 (DiPaSE):高GC生物合成遺伝子クラスタの正確かつ効率的なリファクタリングのためのワンポットDNAアセンブリ方法

Tomoki Takeda1,2, Misaki Aso1, Hiroko Ueda1

  • 1Institute for Advanced Biosciences, Keio University, Tsuruoka, Yamagata 997-0017, Japan.

ACS synthetic biology
|February 12, 2026
PubMed
まとめ

私たちは,アクティノバクテリアの大きな高GC生物合成遺伝子クラスタを効率的に編集するための新しい方法である直接経路合成および編集 (DiPaSE) を開発しました. このツールは,天然製品の発見とバイオシンセシスのエンジニアリングを強化します.

キーワード:
アクチノバクテリアは,アクチノバクテリアを生物合成遺伝子クラスター微生物による化学生産マルチプレックスDNA編集合成生物学 合成生物学とは

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Amino Acid Biosynthetic Pathways01:29

Amino Acid Biosynthetic Pathways

Amino acid biosynthesis is essential for cell growth, protein synthesis, and metabolic regulation. Cells generate essential and non-essential amino acids from metabolic intermediates to sustain vital biological functions. These intermediates originate from key metabolic pathways: glycolysis, the tricarboxylic acid (TCA) cycle, and the pentose phosphate pathway. Important precursors include α-ketoglutarate, pyruvate, oxaloacetate, phosphoenolpyruvate, and erythrose-4-phosphate, which...
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Direct Motor Pathways01:11

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Cluster Sampling Method01:20

Cluster Sampling Method

Appropriate sampling methods ensure that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
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RNA Editing02:23

RNA Editing

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From DNA to Protein

The flow of genetic information in cells from DNA to mRNA to protein is described by the central dogma, which states that genes specify the sequence of mRNAs, which in turn specify the sequence of amino acids making up all proteins. The decoding of one molecule to another is performed by specific proteins and RNAs. Because the information stored in DNA is so central to cellular function, it makes intuitive sense that the cell would make mRNA copies of this information for protein synthesis...
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mRNA Stability and Gene Expression

The structure and stability of mRNA molecules regulates gene expression, as mRNAs are a key step in the pathway from gene to protein. In eukaryotes, the half-life of mRNA varies from a few minutes up to several days. mRNA stability is essential in growth and development. The absence of the proteins regulating its stability, such as tristetraprolin in mice, can cause systemic issues, including bone marrow overgrowth, inflammation, and autoimmunity.
Cis-acting Elements involved in mRNA stability
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