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Updated: Feb 13, 2026

Deciphering the Structural Effects of Activating EGFR Somatic Mutations with Molecular Dynamics Simulation
15:05

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Published on: May 20, 2020

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N6-メチラデノシンRNAと複合したYTHドメインの構造的および動的性質は,加速分子ダイナミクスシミュレーションによって研究されました

Mingwei Li1, Guanglin Chen2, Zhiyong Zhang1,2

  • 1MOE Key Laboratory for Membraneless Organelles & Cellular Dynamics National Science Center for Physical Sciences at Microscale Division of Life Sciences and Medicine, and Biomedical Sciences and Health Laboratory of Anhui Province University of Science and Technology of China Hefei 230026 China.

Quantitative biology (Beijing, China)
|February 12, 2026
PubMed
まとめ

YTHドメインは,非メチル化RNAよりもメチル化RNAをより効果的に結合し,この相互作用に関与する主要な水性残基を明らかにします. この研究は,YTH-RNAの複雑なダイナミクスと結合メカニズムの理解を深める.

キーワード:
RNAメチレーションによるRNAメチレーションYTH-m6A3RNAをRNAとして利用しています.拘束力のある自由エネルギーコンタクトベースのPCA主要コンポーネント分析 (PCA)

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Author Spotlight: In Silico Creation and Impact of Carbonylated Amino Acids on Protein Structure and Function05:57

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