L-ライシンとHoldemanella biformisの相互相互作用は,刺激性腸症候群における腸の障壁機能と不安を調節する
Chun-Hui Jiang1, Xue Fang1, Wen Huang1
1Department of Gastroenterology, Shanghai Key Laboratory of Nautical Medicine and Translation of Drugs and Medical Devices, Changhai Hospital; National Key Laboratory of Immunity and Inflammation Naval Medical University Shanghai China.
iMetaOmics
|February 12, 2026
まとめ
研究者らは,低レベルのl-リシンと,刺激性腸症候群 (IBS) の腸内細菌ホルデマンエラ・ビフォームスの増加との関連性を発見した. この相互作用は,腸の障壁機能と不安に影響を与え,IBSと腸-脳軸障害の潜在的な治療標的を提供します.
科学分野:
- 微生物学 微生物学とは
- メタボロミクスとは
- 神経胃腸内科 神経胃腸内科
背景:
- 刺激性腸症候群 (IBS) は,ストレス,腸の障壁問題,腸-脳軸機能不全に関連した一般的な疾患です.
- IBSにおける宿主代謝産物と腸内微生物の特定の役割は完全に理解されていません.
研究 の 目的:
- IBSの病原性における宿主代謝産物と腸内微生物の相互作用を調査する.
- ストレス誘発性IBSに関連した特定の微生物および代謝変化を特定するために.
主な方法:
- 航海前に及び航海後に海員から採取した糞便サンプルを集積した微生物群及び代謝群のプロファイリング.
- 介入研究 (l-ライシン補充とH. biformis投与) のために,下痢が優勢であるIBSのマウスモデルを使用しました.
- L-リジンとH. biformisが上皮細胞に及ぼす影響を調べるために,in vitro実験を実施した.
主要な成果:
- L-ライシンと腸内細菌のホルデマネラ・ビフォームス (H. biformis) の間の相互相互作用が確認されました.
- l-ライシンが枯渇し,H. biformisの豊富さは,航海によって引き起こされたIBS.を持つ個体で増加した.
- マウスにおけるl-ライシン補給は,腸壁の整合性を改善し,過敏症と不安を軽減し,H. biformisの投与は不安を悪化させた.
- 実験室内研究では,l-ライシンとH.biformisの両方が,上皮の治癒とZO-1発現を促進することを示しました.
結論:
- L-ライシンとH. biformisの間には,ストレスに敏感で双方向的な代謝ループが存在し,腸や神経機能に影響を与えます.
- この軸は,腸の障壁の整合性と不安のような行動に対して,互いを補完するが,対極的な影響を及ぼします.
- L-ライシン-H.ビフォームス軸をターゲットにすることは,IBSやその他の腸-脳軸の障害に対する潜在的な治療戦略です.
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