ステアトス性肝疾患に対するビタミンDサプリメント: ランダム化および非ランダム化介入研究の更新された系統的レビューおよび用量反応メタ解析
Ehsaneh Taheri1, Shirin Esmaeili2, Fatemeh Jodeiri3
1Digestive Diseases Research Institute, Tehran University of Medical Sciences, Tehran, Iran.
Current developments in nutrition
|February 12, 2026
まとめ
代謝機能障害に関連したステアトス性肝疾患 (MASLD) のビタミンDサプリメントは,肝臓酵素と代謝マーカーのわずかな改善を示したが,有意な臨床的利益はなかった. この介入は安全でしたが,MASLD患者にとって有意義な利点はありませんでした.
科学分野:
- 肝臓病理学 肝臓病理学
- エンドクリノロジー エンドクリノロジー
- 栄養科学とは,栄養科学である.
背景:
- 代謝機能障害に関連したステアトス性肝疾患 (MASLD) は,治療の選択肢が限られている慢性肝疾患である.
- ビタミンDのサプリメントは,提案された安全性と有効性のために,MASLDに対する潜在的な介入として調査されています.
- 現在の証拠は,MASLDに対するビタミンDの臨床的影響を決定するために,体系的な評価を必要とする.
研究 の 目的:
- MASLD患者の肝臓と代謝のパラメータに対するビタミンDサプリメントの影響を体系的に評価する.
- ビタミンDサプリメントのアウトカムとベースラインおよび/またはプラセボの反応を比較する.
- 潜在的な患者のサブセットや,治療効果に関連した介入の特徴を特定するためです.
主な方法:
- 関連する研究について,複数のデータベース (MEDLINE,Scopus,Web of Science,Cochrane Library, clinicaltrials.gov,ICTRP) で体系的な検索が行われました.
- ランダム効果メタ解析を用いて,28の研究 (21 RCT) のデータをまとめました.
- 治療効果を探求し,影響要因を特定するために,用量反応,メタレグレッション,およびサブグループ分析が行われました.
主要な成果:
- ビタミンDサプリメントは,FibroScanのパラメータ,肝臓酵素 (ALT,GGT),インスリン抵抗性,トリグリセリド,およびHDLコレステロールの統計的に有意な改善を示しました.
- これらの改善の大きさは,臨床的に有意義な値以下であり,分析では不一致が示されました.
- サブグループ分析では,ビタミンDサプリメントから有意に恩恵を受けた特定の患者グループや疾患を特定できませんでした.
結論:
- ビタミンDのサプリメントは,MASLDの患者に安全であり,よく耐えます.
- 特定のマーカーのわずかな改善にもかかわらず,ビタミンDサプリメントは,MASLDの肝臓または代謝のパラメータに対して有意な臨床的利点を提供しませんでした.
- MASLDの管理におけるビタミンDの役割 (ある場合) を明らかにするために,さらなる研究が必要になる可能性があります.
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