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Updated: Feb 13, 2026

Biochemical Assays for Analyzing Activities of ATP-dependent Chromatin Remodeling Enzymes
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Published on: October 25, 2014

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LRRK2のROC依存活性化の構造と生化学的基礎

Quyen Hoang, Yangshin Park, Chunxiang Wu

    Research square
    |February 12, 2026
    PubMed
    まとめ

    レウシンに富んだリピートキナーゼ2 (LRRK2) のパーキンソン病変異は,そのRas複合タンパク質 (ROC) ドメインと関連しています. この研究では,ROCコンフォメーションスイッチングが,分子内経路を通じてLRRK2の活性化を誘導することを明らかにしています.

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