Jove
Visualize
お問い合わせ
JoVE
x logofacebook logolinkedin logoyoutube logo
JoVEについて
概要リーダーシップブログJoVEヘルプセンター
著者向け
出版プロセス編集委員会範囲と方針査読よくある質問投稿
図書館員向け
推薦の声購読アクセスリソース図書館諮問委員会よくある質問
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experimentsアーカイブ
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教員リソースセンター教員サイト
利用規約
プライバシーポリシー
ポリシー

関連する概念動画

Fates of Pyruvate01:20

Fates of Pyruvate

11.2K
Pyruvate is the end product of glycolysis, where glucose is oxidized to pyruvate, simultaneously reducing NAD+ to NADH. Two molecules of ATP are also produced by substrate-level phosphorylation.
In aerobic organisms, pyruvate is metabolized via the citric acid cycle to produce reduced coenzymes NADH and FADH2. These coenzymes are then oxidized in the electron transport chain to produce ATP and, in the process, regenerate the NAD+ and FAD. As seen in some cell types and organisms, fermentation...
11.2K
Quantifying Work02:30

Quantifying Work

24.5K
As a system undergoes a change, its internal energy can change, and energy can be transferred from the system to the surroundings, or from the surroundings to the system.
24.5K
Cell Specific Gene Expression01:58

Cell Specific Gene Expression

16.6K
Multicellular organisms contain a variety of structurally and functionally distinct cell types, but the DNA in all the cells originated from the same parent cells. The differences in the cells can be attributed to the differential gene expression. Liver cells, whose functions include detoxification of blood, production of bile to metabolize fats, and synthesis of proteins essential for metabolism, must express a specific set of genes to perform their functions. Gene expression also varies with...
16.6K
Global Climate Change01:50

Global Climate Change

29.0K
Throughout its ~4.5 billion year history, the Earth has experienced periods of warming and cooling. However, the current drastic increase in global temperatures is well outside of the Earth’s cyclic norms, and evidence for human-caused global climate change is compelling. Paleoclimatology, the study of ancient climate conditions, provides ample evidence for human-caused global climate change by comparing recent conditions with those in the past.
29.0K
Personal Choice and Fate Attributions01:19

Personal Choice and Fate Attributions

182
Some individuals interpret life events as a consequence of their personal choices and actions, while others believe that outcomes are dictated by fate or destiny. This divergence in perspective has been examined in psychological and cross-cultural studies, particularly in relation to religious faith and cultural beliefs about causality.Fate and Personal ResponsibilityPeople who emphasize personal responsibility view events as direct consequences of their decisions. For instance, breaking a leg...
182
Rates of Change01:20

Rates of Change

134
The rate of change is a central concept in mathematics that quantifies how one variable varies in response to another. It serves as a foundational tool in modeling dynamic systems across disciplines such as physics, biology, economics, and engineering. Understanding both average and instantaneous rates of change enables the analysis of behavior in functions that describe real-world phenomena.Average Rate of ChangeFor a function f(x) defined over an interval [x1,x2], the average rate of change...
134

こちらも読む

関連記事

共著者、ジャーナル、引用グラフによってこの研究に関連する記事。

並び替え
Same author

A Mosquito Population Suppression Model by Releasing Wolbachia-Infected Males.

Bulletin of mathematical biology·2022
Same author

Quantification of transcription noise's impact on cell fate commitment with digital resolutions.

Bioinformatics (Oxford, England)·2022
Same author

Using average transcription level to understand the regulation of stochastic gene activation.

Royal Society open science·2022
Same author

Mosquito Control Based on Pesticides and Endosymbiotic Bacterium Wolbachia.

Bulletin of mathematical biology·2021
Same author

[Field resistance of Phytophthora melonis to metalaxyl in South China].

Wei sheng wu xue bao = Acta microbiologica Sinica·2011
Same author

Anatomical and physiological plasticity in Leymus chinensis (Poaceae) along large-scale longitudinal gradient in northeast China.

PloS one·2011

関連する実験動画

Updated: Feb 13, 2026

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

15.9K

異なるストキャスティック遺伝子活性化フレームワークの下で細胞運命の変化を定量化する.

Xinxin Chen1, Ying Sheng1, Liang Chen1

  • 1Guangzhou Center for Applied Mathematics Guangzhou University Guangzhou China.

Quantitative biology (Beijing, China)
|February 12, 2026
PubMed
まとめ

細胞の運命の決定は,遺伝子転写レベルに依存しています. この研究は,転写値モデルを導入し,遺伝子のアップレギュレーションが細胞の運命の変化を抑制し,ノイズが細胞の運命に双方向的に影響することを示しています.

キーワード:
細胞の運命が変わるmRNAの分布について統計の転写の値である.ストカスティック遺伝子転写 ストカスティック遺伝子転写トランスクリプションノイズ

さらに関連する動画

Single Cell Fate Mapping in Zebrafish
07:53

Single Cell Fate Mapping in Zebrafish

Published on: October 5, 2011

13.9K
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

10.6K

関連する実験動画

Last Updated: Feb 13, 2026

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development
14:08

Blastomere Explants to Test for Cell Fate Commitment During Embryonic Development

Published on: January 26, 2013

15.9K
Single Cell Fate Mapping in Zebrafish
07:53

Single Cell Fate Mapping in Zebrafish

Published on: October 5, 2011

13.9K
Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
08:29

Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel

Published on: May 14, 2018

10.6K

科学分野:

  • * 分子生物学 * 分子生物学
  • * システム生物学
  • * バイオフィジックス

背景:

  • * 遺伝子転写は本質的にストキャスティックであり,同一の細胞におけるmRNAレベル変動につながる.
  • * 転写の多様性が細胞の運命をどのように影響するかを理解することは,単細胞生物学において極めて重要です.
  • *以前のモデルは,転写ダイナミクスを分析しましたが,複雑な遺伝子活性化フレームワークへの拡張が必要でした.

研究 の 目的:

  • *遺伝子転写確率 (J_I) の数学的枠組みを,より複雑な遺伝子活性化モデルに拡張する.
  • * 細胞運命を決定する上で重要な遺伝子アップレギュレーションの影響を調査する.
  • * 細胞運命の変化を調節するトランスクリプションノイズの二重の役割を分析する.

主な方法:

  • * 複雑な遺伝子活性化モデルを開発・分析し,古典的な電信モデルを超えた.
  • * 細胞が特定の転写値 (I) に到達する確率 (J_I) を計算した.
  • * バクテリア,酵母,哺乳類の細胞からの実験データを用いて検証されたモデル予測.

主要な成果:

  • * 重要な遺伝子のアップレギュレーションが,細胞運命の移行を著しく抑制することが判明しました.
  • * 転写ノイズには双方向効果があり,細胞運命を変化させたり,抑制したりします.
  • * 転写値 (I) は,様々な細胞データから成功裏に推定されました.

結論:

  • *この研究は,転写ダイナミクスに基づく細胞運命のコミットメントを予測するための洗練されたモデルを提供します.
  • *研究結果は,高用量のHIV活性化剤が,ウイルスの再活性化を抑制する可能性があることを示唆しています.
  • * 細胞は,生存のために環境のストレスに基づいて,遺伝子調節ノイズを動的に調整することができる.