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ペムブロリズマブ関連性大動脈炎の3重陰性乳がん患者:症例報告
Nicolas Ardila1, Camila A Guerrero Bermúdez1, Sergio A Tasco Múnera2
1Internal Medicine, Universidad de Antioquia, Medellín, COL.
Cureus
|February 12, 2026
まとめ
ペンブロリズマブのような免疫チェックポイント阻害剤は,まれなアオルティスを引き起こす可能性があります. この症例報告は,ペムブロリズマブ治療の後にオーート炎を発症した乳がん患者の詳細を記載しており,コルチコステロイドでうまく管理されています.
科学分野:
- 腫瘍学 腫瘍学
- 免疫学 免疫学とは
- 心臓病学 心臓病学
背景:
- 免疫チェックポイント阻害剤 (ICI) は,がん治療に革命をもたらしました.
- しかし,ICIは免疫関連の有害事象 (irAEs) を引き起こす可能性があります.
- 血管性IRAEは稀であるが,重症である可能性があります.
研究 の 目的:
- 三重陰性乳癌の患者でペムブロリズマブに関連した甲状腺炎の希少な症例を報告する.
- ICI誘発性大動脈炎の診断と管理の課題を強調する.
- 血管性IRAEの認識の重要性を強調する.
主な方法:
- トリプルネガティブな乳がんを患った47歳の女性の症例報告.
- 詳細な臨床プレゼンテーション,診断作業 (イメージング,ラボ) と治療コース.
- ペムブロリズマブ投与と時の関連性のレビュー.
主要な成果:
- 患者はペムブロリズマブ注入から3日後に急性オーート炎を発症した.
- 画像検査により,拡散性大動脈炎症性濃縮が確認されました.
- 高用量のコルチコステロイドによる治療は,迅速な臨床および炎症マーカーの改善につながった.
- フォローアップ画像は,大動脈炎の完全な解消と癌の再発を示しました.
結論:
- ペムブロリズマブ関連アオルチス (Pembrolizumab-associated aortitis) は,免疫関連の有害事象であり,まれであるが深刻である.
- 迅速な診断とコルチコステロイド治療は,好ましい結果を得るために不可欠です.
- このケースは,ICIを受けている患者の血管合併症に関して警戒する必要性を強調しています.
キーワード:
アオルチス (aortitis) とは,アオルチス (aortitis) とは,アオルチス (aortitis) とは免疫チェックポイント阻害剤免疫関連の有害事象 (IRAE) とはペンブロリズマブ (Pembrolizumab) は,ペムブロリズマブ (Pembrolizumab) とも呼ばれています.ペンブロリズマブの副作用についてトリプルネガティブ乳がん (tnbc)さらに関連する動画
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