新生児重症病棟に入院した乳児の低用量と高用量クロニジンの比較
Jacob Kelner1,2, Clare Riotte2,3, Ursula Marquis4
1Division of Neonatology (JK, SL), Connecticut Children's, Hartford, CT.
まとめ
低用量の腸内クロニジン (LDC) を開始すると,新生児重症治療室 (NICU) の新生児の痛み,動揺,オピオイド離脱の管理に高用量の腸内クロニジン (HDC) と同じくらい効果があるようです. この発見は,LDCを有効な初期治療戦略として支持しています.
科学分野:
- 新生児薬理学 新生児薬理学
- 小児重症の重症療養は小児重症の重症療養として行われます.
背景:
- オピオイド離脱と興奮は,高リスクの新生児集中治療室 (NICU) の乳児において一般的です.
- 腸内クロニジンはこれらの症状を管理するために使用されますが,最適な用量戦略についてはさらなる調査が必要です.
研究 の 目的:
- 乳幼児のNICUでの痛み,興奮,オピオイド離脱の治療のために,低用量対高用量での腸内クロニジンの開始の有効性を比較するために.
主な方法:
- 月経後50週前に腸内クロニジンを投与したIVレベルNICUの95人の乳児の遡及的チャートレビュー.
- 乳児は低用量 (LDC:<4mcg/kg/day) と高用量 (HDC:≥4mcg/kg/day) のグループに分けられた.
- 新生児の痛み,興奮,鎮静スケール (N-PASS) のスコアを含む,治療の30日間のアウトカムの比較.
主要な成果:
- LDC (n=41) とHDC (n=54) のグループでは統計的に有意な人口格差は見られなかった.
- LDCとHDCの両グループは,30日間の治療期間中にN-PASSスコアの同様の低下を示しました.
- LDCグループは,HDCグループ (8mcg/kg/day) と比較して,クロニジンの最大投与量 (4mcg/kg/day) を低くした.
結論:
- 低用量での腸内クロニジンの開始は,NICUの乳児の痛み,興奮,オピオイド離脱の管理に高用量と同じくらい有効である可能性があります.
- この観察研究は,LDCを潜在的に効果的な代替初期投与戦略として示唆しています.
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